Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1580970 | 0.81 | NOTUM (0.47) | NOTUMMEN1KMT2A | |
| SCHEMBL1052098 | 0.78 | NOTUM (0.39) | NOTUMS1PR5S1PR1GRK5CDK8 | |
| SCHEMBL3724546 | 0.76 | KDM1A (0.47) | NOTUMMEN1KMT2AKCNH2CHRNB2 | |
| SCHEMBL21381616 | 0.75 | PTGDR2 (0.43) | NOTUMMEN1KMT2APDE2ADPP4 | |
| SCHEMBL20299307 | 0.71 | FFAR4 (0.44) | MEN1KMT2APDE2AGRM2GRM3 | |
| SCHEMBL3725480 | 0.71 | EPHX2 (0.40) | NOTUMS1PR5S1PR1KCNH2 | |
| SCHEMBL3720678 | 0.71 | HRH3 (0.41) | NOTUMS1PR5S1PR1PRKXIKBKE | |
| SCHEMBL582163 | 0.70 | NOTUM (0.46) | NOTUMMEN1KMT2A | |
| SCHEMBL1056674 | 0.70 | CHRNB2 (0.50) | MEN1KMT2APDE2ACHRNB2CHRNA4 | |
| SCHEMBL21381692 | 0.69 | MAPT (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136144-A1 | SUBSTITUTED PIPERIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-12-02 | — | — | WO | disclosed |