Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.40 |
| ▸ | ITGAL | P20701 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724732 | 0.86 | KDM4E (0.46) | TRPV1JAK2JAK1MCHR1MAP4K4 | |
| SCHEMBL3727182 | 0.85 | HSD17B10 (0.41) | JAK2JAK1MCHR1MAPK1HSD17B10 | |
| SCHEMBL3720582 | 0.80 | HRH4 (0.45) | TRPV1MCHR1MAPK1HSD17B10 | |
| SCHEMBL3727426 | 0.77 | KDM4E (0.48) | MCHR1MAPK1HSD17B10 | |
| SCHEMBL3723892 | 0.77 | KDM4E (0.48) | MCHR1MAPK1HSD17B10 | |
| SCHEMBL3720441 | 0.76 | MAPT (0.53) | — | |
| SCHEMBL3724664 | 0.76 | HRH4 (0.57) | MAPK1HSD17B10 | |
| SCHEMBL893206 | 0.76 | TRPA1 (0.51) | — | |
| SCHEMBL3727177 | 0.75 | KDM4E (0.46) | MCHR1HSD17B10 | |
| SCHEMBL3724014 | 0.74 | HRH4 (0.43) | TRPV1MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |