Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725420 | 0.86 | HSD17B10 (0.50) | MAPTSMN1; SMN2PARP1PARP2HRH4 | |
| SCHEMBL3720439 | 0.85 | KDM4E (0.53) | MAPTSMN1; SMN2HPGDHTTNPC1 | |
| SCHEMBL3724664 | 0.82 | HRH4 (0.57) | MAPTSMN1; SMN2HPGDHTTHRH4 | |
| SCHEMBL3797918 | 0.80 | HRH4 (0.44) | SMN1; SMN2HPGDHRH4CYP11B2TP53 | |
| SCHEMBL3718066 | 0.79 | HRH4 (0.43) | MAPTSMN1; SMN2HPGDHRH4CYP11B2 | |
| SCHEMBL3722161 | 0.79 | HRH4 (0.53) | MAPTSMN1; SMN2HPGDHTTHRH4 | |
| SCHEMBL3720932 | 0.78 | IDH2 (0.44) | HPGDPOLBHRH4TP53 | |
| SCHEMBL3721777 | 0.78 | HRH3 (0.42) | SMN1; SMN2HPGDHRH4CYP11B2TP53 | |
| SCHEMBL3721072 | 0.78 | CYP11B2 (0.46) | MAPTSMN1; SMN2HPGDHRH4CYP11B2 | |
| SCHEMBL3724736 | 0.76 | TRPV1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |