Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 6/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724793 | 1.00 | ALDH1A1 (0.51) | ALDH1A1MAPTNPC1MAPK1HTT | |
| SCHEMBL3720046 | 0.94 | ALDH1A1 (0.58) | ALDH1A1MAPTNPC1MAPK1HTT | |
| SCHEMBL3724794 | 0.87 | USP30 (0.56) | POLBUSP30THRBLMNA | |
| SCHEMBL4940990 | 0.87 | USP30 (0.56) | POLBUSP30THRBLMNA | |
| SCHEMBL3671324 | 0.85 | LMNA (0.46) | MAPTPOLBUSP30THRBLMNA | |
| SCHEMBL3727246 | 0.84 | BRD4 (0.49) | ALDH1A1MAPTNPC1MAPK1HTT | |
| SCHEMBL3727248 | 0.84 | BRD4 (0.49) | ALDH1A1MAPTNPC1MAPK1HTT | |
| SCHEMBL3720050 | 0.83 | POLB (0.60) | MAPTPOLBUSP30THRBLMNA | |
| SCHEMBL3668808 | 0.81 | LMNA (0.49) | MAPTPOLBTHRBLMNATP53 | |
| SCHEMBL3671327 | 0.81 | USP30 (0.66) | USP30GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155719-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008147945-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-12-04 | — | — | WO | disclosed |