Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.60 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL3724837 | 1.00 | SLC7A5 (0.60) | SLC7A5SLC1A3SLC1A2GRIK1EPHX1 | |
| Leucine SCHEMBL6369629 | 0.86 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2GRIK1EPHX1 | |
| Leucine SCHEMBL6369626 | 0.86 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2GRIK1EPHX1 | |
| Leucine SCHEMBL6882071 | 0.84 | SLC7A5 (0.53) | SLC7A5SLC1A3SLC1A2GRIK1EPHX1 | |
| Leucine SCHEMBL27975821 | 0.83 | SLC7A5 (0.64) | SLC7A5SLC1A3SLC1A2GRIK1SLC1A1 | |
| Aspartic Acid SCHEMBL27975470 | 0.83 | GRIK1 (0.49) | GRIK1DPP7GRIK2ALDH1A1HSD17B10 | |
| Aspartic Acid SCHEMBL7422744 | 0.83 | GRIK1 (0.49) | GRIK1DPP7GRIK2ALDH1A1HSD17B10 | |
| Aspartic Acid SCHEMBL7422755 | 0.83 | GRIK1 (0.49) | GRIK1DPP7GRIK2ALDH1A1HSD17B10 | |
| Aspartic Acid SCHEMBL7422749 | 0.83 | GRIK1 (0.49) | GRIK1DPP7GRIK2ALDH1A1HSD17B10 | |
| Leucine SCHEMBL7414158 | 0.83 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2GRIK1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2707347-A1 | PROCESSES AND INTERMEDIATES | Vertex Pharmaceuticals Inc. (US) | 2014-03-19 | — | — | EP | disclosed |
| EP-2576508-A2 | PROCESSES AND INTERMEDIATES | Vertex Pharmaceuticals Incorporated (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2012158513-A1 | PROCESSES AND INTERMEDIATES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-22 | — | — | WO | disclosed |
| CN-101291909-B | Processes and intermediates | VERTEX PHARMA | 2012-09-05 | — | — | CN | disclosed |
| EP-2477966-A1 | PROCESSES AND INTERMEDIATES | Vertex Pharmaceuticals Incorporated (US) | 2012-07-25 | — | — | EP | disclosed |
| CN-102382170-A | Method for preparation of protease inhibitors and intermediates | VERTEX PHARMA | 2012-03-21 | — | — | CN | disclosed |
| WO-2011153423-A2 | PROCESSES AND INTERMEDIATES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-12-08 | — | — | WO | disclosed |
| WO-2010126881-A1 | PROCESSES AND INTERMEDIATES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-04 | — | — | WO | disclosed |
| CN-101291909-A | Processes and intermediates | VERTEX PHARMA (US) | 2008-10-22 | — | — | CN | disclosed |
| EP-1934179-A2 | PROCESSES AND INTERMEDIATES | Vertex Pharmaceuticals Incorporated (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007022459-A2 | PROCESSES AND INTERMEDIATES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-02-22 | — | — | WO | disclosed |