Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 2/20 | 0.54 |
| ▸ | CCND1 | P24385 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | ICMT | O60725 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714231 | 0.87 | NR4A2 (0.63) | NR4A2RAB9ALMNAKDM4EHSD17B10 | |
| SCHEMBL8109983 | 0.87 | NR4A2 (0.67) | NR4A2RAB9ALMNAKDM4EHSD17B10 | |
| SCHEMBL2540059 | 0.84 | NR4A2 (0.50) | NR4A2RAB9ALMNAKDM4EHSD17B10 | |
| SCHEMBL7287695 | 0.84 | LMNA (0.68) | NR4A2RAB9ALMNAKDM4EHSD17B10 | |
| SCHEMBL3976054 | 0.83 | NR4A2 (0.71) | NR4A2RAB9ALMNAKDM4EHSD17B10 | |
| SCHEMBL27811127 | 0.81 | HSD17B10 (0.79) | NR4A2RAB9ALMNAKDM4EHSD17B10 | |
| SCHEMBL2536745 | 0.81 | NR4A2 (0.47) | NR4A2RAB9ALMNAKDM4EHSD17B10 | |
| SCHEMBL6030284 | 0.81 | NR4A2 (0.73) | NR4A2RAB9ALMNAKDM4EHSD17B10 | |
| SCHEMBL2535534 | 0.81 | F7 (0.71) | NR4A2CDK4CCND1F7F3 | |
| SCHEMBL21366320 | 0.81 | KDM4E (0.59) | KDM4EALDH1A1CDK4CCND1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010139982-A1 | INDOLE DERIVATIVES FOR THE STIMULATION OF STEM CELL PROLIFERATION | THE UNIVERSITY OF SHEFFIELD (GB) | 2010-12-09 | — | — | WO | disclosed |