Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3873604 | 1.00 | ESR1 (0.50) | ESR1ESR2L3MBTL1ALDH1A1GAA | |
| SCHEMBL3667647 | 1.00 | ESR1 (0.50) | ESR1ESR2L3MBTL1ALDH1A1GAA | |
| SCHEMBL6667251 | 0.85 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1GAALMNATDP1 | |
| SCHEMBL7163969 | 0.83 | FFAR1 (0.53) | L3MBTL1ALDH1A1GAALMNAMMP9 | |
| SCHEMBL6461974 | 0.81 | L3MBTL1 (0.62) | ESR1ESR2L3MBTL1ALDH1A1GAA | |
| SCHEMBL28017822 | 0.81 | L3MBTL1 (0.62) | ESR1ESR2L3MBTL1ALDH1A1GAA | |
| SCHEMBL3657646 | 0.80 | KYNU (0.43) | L3MBTL1ALDH1A1GAALMNACYP3A4 | |
| SCHEMBL3707355 | 0.80 | KYNU (0.43) | L3MBTL1ALDH1A1GAALMNACYP3A4 | |
| SCHEMBL2498906 | 0.80 | KYNU (0.43) | L3MBTL1ALDH1A1GAALMNACYP3A4 | |
| SCHEMBL3715508 | 0.79 | ESR1 (0.44) | ESR1ESR2ALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139843-A1 | SUBSTITUTED BIPHENYL PHENOXY-, THIOPHENYL- AND AMINOPHENYLPROPANOIC ACID GPR40 MODULATORS | Amgen, Inc (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008130514-A1 | SUBSTITUTED BIPHENYL PHENOXY-, THIOPHENYL- AND AMINOPHENYLPROPANOIC ACID GPR40 MODULATORS | AMGEN INC. (US) | 2008-10-30 | — | — | WO | disclosed |