SCHEMBL372545

SCHEMBL372545

CN1CC[N]C(=O)C1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL596930 0.86 BRD4 (0.39)
SCHEMBL182572 0.74
SCHEMBL11483414 0.72 L3MBTL1 (0.39)
SCHEMBL25693311 0.68
SCHEMBL717518 0.68 BRD4 (0.43)
SCHEMBL20024973 0.65 HTT (0.32)
SCHEMBL9098558 0.65 DGAT1 (0.30)
SCHEMBL14428797 0.64 BRD4 (0.52)
SCHEMBL1690690 0.63
SCHEMBL4871 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 179 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3560499-A1 DIHYDROPTERIDINONES FOR THE TREATMENT OF CANCER DISEASES Boehringer Ingelheim International GmbH (DE) 2019-10-30 EP claimed
US-8591895-B2 Combinations for the treatment of diseases involving cell proliferation BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-11-26 US claimed
US-20130245013-A1 STORAGE STABLE PERFUSION SOLUTION FOR DIHYDROPTERIDINONES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-09-19 US claimed
EP-1778668-B1 METHOD FOR THE PRODUCTION OF DIHYDROPTERIDINONES BOEHRINGER INGELHEIM INT (DE) 2013-07-03 EP claimed
US-20120329803-A1 Dihydropteridinones, method for production and use thereof BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-12-27 US claimed
EP-2536725-A1 DIHYDROPTERIDINONES, METHOD FOR PRODUCTION AND USE THEREOF Boehringer Ingelheim International GmbH (DE) 2012-12-26 EP claimed
US-20120107312-A1 Combinations for the Treatment of Diseases involving Cell Proliferation BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-05-03 US claimed
EP-2409706-A1 DIHYDROPTERIDINONES FOR THE TREATMENT OF CANCER DISEASES Boehringer Ingelheim International GmbH (DE) 2012-01-25 EP claimed
WO-2011101369-A1 DIHYDROPTERIDINONES, METHOD FOR PRODUCTION AND USE THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-08-25 WO claimed
WO-2006018221-A9 DIHYDROPTERIDINONE INFUSION SOLUTION HAVING A LONG SHELF LIFE BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-04-28 WO claimed
US-5420272-A 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines AMERICAN CYANAMID COMPANY (US) 1995-05-30 US claimed
US-5328902-A Antibiotics AMERICAN CYANAMID CO. (US) 1994-07-12 US claimed
CN-1087626-A The glycyl that novel 7-(replacement)-8-(replacement)-9-[(replaces) amido]-6-demethyl-6-deoxidation tsiklomitsin AMERICAN CYANAMID CO (US) 1994-06-08 CN claimed
CN-1083805-A 7-(replacement)-9-[(substituted glycyl) amido]-6-demethylation-6-deoxytetra cycline AMERICAN CYANAMID CO (US) 1994-03-16 CN claimed
EP-0582789-A1 Novel 7-(substituted)-8-(substituted)-9- (substituted glycyl)amido -6-demethyl-6-deoxytetracyclines AMERICAN CYANAMID COMPANY (US) 1994-02-16 EP claimed
EP-0582788-A1 7-(Substituted)-9- (substituted glycyl)-amido)-6-demethyl-6-deoxytetracyclines AMERICAN CYANAMID COMPANY (US) 1994-02-16 EP claimed
US-4570000-A HISTAMINE HH-2 ANTAGONISTS; GASTROINTESTINAL DISORDERS IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) 1986-02-11 US claimed
EP-0060696-B1 NITROGEN HETEROCYCLES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-01-15 EP claimed
EP-0060696-A1 Nitrogen heterocycles IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-09-22 EP claimed
US-4226864-A BACTERICIDES, ANTIBIOTICS SHIONOGI & CO., LTD. (JP) 1980-10-07 US claimed