Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 13/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.45 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634902 | 0.79 | SSTR5 (0.67) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL3638623 | 0.78 | SSTR5 (0.67) | SSTR5HRH1HTR2B | |
| SCHEMBL4004390 | 0.77 | SSTR5 (0.47) | SSTR5HRH1KCNH2 | |
| SCHEMBL4000512 | 0.76 | SSTR5 (0.46) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL3634985 | 0.74 | SSTR5 (0.45) | SSTR5HRH1KCNH2 | |
| SCHEMBL3727948 | 0.73 | SSTR5 (0.49) | SSTR5HRH1HTR2BS1PR1ACHE | |
| SCHEMBL3997486 | 0.73 | SSTR5 (0.52) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL3977776 | 0.73 | SSTR5 (0.50) | SSTR5HRH1HTR2B | |
| SCHEMBL3639902 | 0.72 | SSTR5 (0.42) | SSTR5HRH1HTR2BSSTR1 | |
| SCHEMBL1873099 | 0.71 | SSTR5 (0.61) | SSTR5HRH1HTR2BSSTR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155718-A2 | ARYLOXAZOLE, ARYLOXADIAZOLE AND BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF SOMATOSTATINE RECEPTOR ACTIVITY | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008148710-A2 | ARYLOXAZOLE, ARYLOXADIAZOLE AND BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF SOMATOSTATINS RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-11 | — | — | WO | disclosed |