Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 19/20 | 0.52 |
| ▸ | HRH1 | P35367 | 5/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971809 | 0.86 | SSTR5 (0.52) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4000428 | 0.83 | SSTR5 (0.56) | SSTR5HRH1HTR2BKCNH2 | |
| SCHEMBL3973407 | 0.82 | SSTR5 (0.47) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4000990 | 0.81 | SSTR5 (0.52) | SSTR5HRH1KCNH2HCRTR1HCRTR2 | |
| SCHEMBL4004390 | 0.79 | SSTR5 (0.47) | SSTR5HRH1KCNH2 | |
| SCHEMBL4002555 | 0.78 | NPC1 (0.43) | SSTR5HRH1HTR2B | |
| SCHEMBL4000512 | 0.78 | SSTR5 (0.46) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL1871649 | 0.78 | SSTR5 (0.68) | SSTR5HRH1HTR2BSSTR1 | |
| SCHEMBL1880126 | 0.78 | SSTR5 (0.68) | SSTR5HRH1HTR2B | |
| SCHEMBL3996567 | 0.78 | SSTR5 (0.46) | SSTR5HRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066658-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-10 | — | — | EP | claimed |
| WO-2008031735-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | WO | claimed |