Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | S100B | P04271 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL8754495 | 0.92 | ALDH1A1 (0.43) | ALDH1A1CYP3A4RECQLPSMD14L3MBTL1 | |
| SCHEMBL29375628 | 0.89 | CYP3A4 (0.42) | ALDH1A1CYP3A4RECQLL3MBTL1TDP1 | |
| SCHEMBL94021 | 0.89 | CYP3A4 (0.42) | ALDH1A1CYP3A4RECQLL3MBTL1TDP1 | |
| SCHEMBL16617493 | 0.86 | CYP3A4 (0.47) | ALDH1A1CYP3A4RECQLPSMD14L3MBTL1 | |
| SCHEMBL29931735 | 0.85 | ALDH1A1 (0.59) | ALDH1A1CYP3A4RECQLPSMD14L3MBTL1 | |
| SCHEMBL1413227 | 0.85 | ALDH1A1 (0.59) | ALDH1A1CYP3A4RECQLPSMD14L3MBTL1 | |
| Hydrochloric Acid SCHEMBL6946148 | 0.83 | CYP3A4 (0.57) | ALDH1A1CYP3A4RECQLPSMD14L3MBTL1 | |
| SCHEMBL16618153 | 0.83 | CYP3A4 (0.44) | ALDH1A1CYP3A4RECQLPSMD14L3MBTL1 | |
| SCHEMBL11067328 | 0.82 | ALDH1A1 (0.60) | ALDH1A1CYP3A4RECQLPSMD14L3MBTL1 | |
| SCHEMBL16617376 | 0.81 | TSHR (0.45) | ALDH1A1CYP3A4RECQLPSMD14L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435436-B1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBVIE INC (US) | 2014-07-30 | — | — | EP | disclosed |
| US-8354422-B2 | Pyrimidine inhibitors of kinase activity | ABBOTT LABORATORIES INC. (US) | 2013-01-15 | — | — | US | disclosed |
| CN-102459264-A | Pyrimidine inhibitors of kinase activity | ABBOTT LAB | 2012-05-16 | — | — | CN | disclosed |
| WO-2010138576-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305126-A1 | Pyrimidine Inhibitors of Kinase Activity | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | disclosed |
| WO-2005058869-A1 | AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-06-30 | — | — | WO | disclosed |
| US-6623914-B2 | Purifying p-phenylenediamine-type color developers in their free-base form by short path distillation including one of a falling film evaporator, a thin film evaporator, a wiped film evaporator, or a short-path evaporator | EASTMAN CHEMICAL COMPANY | 2003-09-23 | — | — | US | disclosed |
| US-20030022114-A1 | Method for preparing an acid salt of p-phenylenediamine-type photographic color developers | BOLDEA LUCIAN (US) | 2003-01-30 | — | — | US | disclosed |
| US-6464734-B1 | USED FOR DYEING OR PRINTING HYDROXYL AND/OR CARBOXAMIDO CONTAINING MATERIALS SUCH AS POLYVINYL ALCOHOL, POLYURETHANES AND POLYAMIDES; WASHFASTNESS | DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) | 2002-10-15 | — | — | US | disclosed |
| EP-1134260-A1 | Deep black dye mixtures of fiber-reactive azo dyes | DyStar Textilfarben GmbH & Co. Deutschland KG (DE) | 2001-09-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305126-A1 | Pyrimidine Inhibitors of Kinase Activity | IGF1R, CDK2, TK1 | ALDH1A1 1481/4885CYP3A4 3650/4885RECQL 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.