Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.31 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.31 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.31 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727019 | 0.88 | HTR2A (0.31) | — | |
| SCHEMBL3723470 | 0.77 | WNT3A (0.36) | PIK3R1PIK3CAMTORRICTORRPTOR | |
| SCHEMBL629349 | 0.76 | JAK2 (0.35) | PIK3R1PIK3CAMTORRICTORRPTOR | |
| SCHEMBL7875027 | 0.73 | CYP2C19 (0.38) | PIK3R1PIK3CAMTORRICTORRPTOR | |
| SCHEMBL414059 | 0.72 | MTOR (0.44) | PIK3R1PIK3CAMTOR | |
| Hydrochloric Acid SCHEMBL22718448 | 0.71 | MTOR (0.43) | PIK3R1PIK3CAMTOR | |
| SCHEMBL413900 | 0.70 | MTOR (0.44) | PIK3R1PIK3CAMTORRICTORRPTOR | |
| SCHEMBL442259 | 0.70 | MTOR (0.44) | PIK3R1PIK3CAMTORRICTORRPTOR | |
| Hydrochloric Acid SCHEMBL443380 | 0.69 | MTOR (0.43) | PIK3R1PIK3CAMTORRICTORRPTOR | |
| Hydrochloric Acid SCHEMBL443379 | 0.69 | MTOR (0.43) | PIK3R1PIK3CAMTORRICTORRPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120996-A1 | 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |