Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | HTR2C | P28335 | 3/20 | 0.31 |
| ▸ | HTR2B | P41595 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727027 | 0.88 | PIK3R1 (0.31) | — | |
| SCHEMBL3723470 | 0.80 | WNT3A (0.36) | — | |
| SCHEMBL7875027 | 0.75 | CYP2C19 (0.38) | MAPT | |
| SCHEMBL629349 | 0.73 | JAK2 (0.35) | — | |
| SCHEMBL3719574 | 0.69 | MTOR (0.54) | — | |
| SCHEMBL7875024 | 0.68 | MTOR (0.38) | MAPT | |
| SCHEMBL2572051 | 0.68 | PNMT (0.42) | HTR2AHTR2CHTR2BMAPT | |
| Hydrochloric Acid SCHEMBL4322406 | 0.67 | PNMT (0.41) | HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL15112869 | 0.66 | C5AR1 (0.37) | HTR2AHTR2CHTR2B | |
| SCHEMBL23493540 | 0.66 | HTR2C (0.51) | HTR2AHTR2CHTR2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120991-A1 | 5, 6, 7, 8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR, PI3, AND HSMG-1 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |