Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | IL1RN | P18510 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841738 | 0.99 | DRD2 (0.43) | DRD2DRD3PLAUANPEPIL1RN | |
| Ammonia Solution, Strong SCHEMBL3737200 | 0.85 | ANPEP (0.45) | DRD2DRD3PLAUANPEPIL1RN | |
| SCHEMBL840448 | 0.83 | PLAU (0.46) | DRD2DRD3PLAUANPEPIL1RN | |
| Ammonia Solution, Strong SCHEMBL3725605 | 0.79 | DRD2 (0.41) | DRD2DRD3PLAU | |
| SCHEMBL841229 | 0.77 | DRD2 (0.42) | DRD2DRD3PLAU | |
| SCHEMBL841194 | 0.77 | DRD2 (0.43) | DRD2DRD3PLAUANPEPIL1RN | |
| Ammonia Solution, Strong SCHEMBL3732398 | 0.76 | DRD2 (0.49) | DRD2DRD3PLAU | |
| Ammonia Solution, Strong SCHEMBL3732439 | 0.75 | DRD2 (0.49) | DRD2DRD3 | |
| Ammonia Solution, Strong SCHEMBL3729586 | 0.75 | DRD2 (0.49) | DRD2DRD3 | |
| SCHEMBL3727066 | 0.75 | ANPEP (0.36) | ANPEPIL1RNERAP2ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |