Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | IL1RN | P18510 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3737203 | 0.85 | CYP19A1 (0.39) | ANPEPIL1RNERAP2ERAP1 | |
| SCHEMBL3725607 | 0.80 | JUN (0.39) | ANPEP | |
| SCHEMBL3732400 | 0.76 | DRD2 (0.34) | ANPEP | |
| SCHEMBL841738 | 0.76 | DRD2 (0.43) | ANPEPIL1RNERAP2ERAP1 | |
| SCHEMBL3729591 | 0.76 | DRD2 (0.38) | — | |
| SCHEMBL3732444 | 0.76 | DRD2 (0.38) | — | |
| Ammonia Solution, Strong SCHEMBL3727065 | 0.75 | DRD2 (0.42) | ANPEPIL1RNERAP2ERAP1 | |
| SCHEMBL3739561 | 0.74 | DRD2 (0.35) | — | |
| SCHEMBL3729932 | 0.69 | BRD4 (0.39) | UCHL1 | |
| SCHEMBL3729955 | 0.68 | AKT2 (0.38) | UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |