SCHEMBL3727971

SCHEMBL3727971

ClCc1ccc(Cl)c(Cl)c1Cl

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.42
MAPK1 P28482 2/20 0.42
PNMT P11086 3/20 0.37
AHR P35869 2/20 0.36
TDP1 Q9NUW8 1/20 0.34
TAAR1 Q96RJ0 1/20 0.33
IDO1 P14902 3/20 0.32
NOTUM Q6P988 1/20 0.32
CYP2A6 P11509 1/20 0.32
CYP2D6 P10635 1/20 0.30
SLC6A2 P23975 1/20 0.30
SLC6A4 P31645 1/20 0.30
SLC6A3 Q01959 1/20 0.30
KMT2A Q03164 2/20 0.30
MEN1 O00255 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9016045 0.88 KMT2A (0.34) PNMTIDO1KMT2A
SCHEMBL4465598 0.80 CYP3A4 (0.43) CYP3A4MAPK1PNMTAHRTDP1
SCHEMBL9482589 0.79 TAAR1 (0.40) CYP3A4MAPK1PNMTAHRTDP1
SCHEMBL11754304 0.79 PNMT (0.34) CYP3A4MAPK1PNMTTAAR1IDO1
SCHEMBL28935815 0.77 MAPK3 (0.31) MAPK1
SCHEMBL18190415 0.77 PNMT (0.33) CYP3A4MAPK1PNMTTAAR1IDO1
SCHEMBL31010416 0.77 MAPK3 (0.31) MAPK1
SCHEMBL2090165 0.76 CYP3A4 (0.40) CYP3A4MAPK1PNMTAHRTDP1
SCHEMBL901121 0.76 CYP3A4 (0.40) CYP3A4MAPK1PNMTAHRTDP1
SCHEMBL283449 0.76 PNMT (0.65) CYP3A4PNMTTAAR1IDO1CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111796040-B Method for separating isomeride chlorobenzene and toluene chloride by adopting gas chromatography-mass spectrometry 南京海关工业产品检测中心 2021-03-16 CN disclosed
CN-111796040-A Method for separating isomeride chlorobenzene and toluene chloride by adopting gas chromatography-mass spectrometry 南京海关工业产品检测中心 2020-10-20 CN disclosed
US-7825141-B2 Epothilone derivatives NOVARTIS AG (CH) 2010-11-02 US disclosed
US-4248988-A CATALYST SYSTEM COMPRISING COBALT OR NICKEL COMPONENT, HYDROCARBYL ALUMINUM, AND HALOGENATED HYDROCARBON THE FIRESTONE TIRE & RUBBER COMPANY (US) 1981-02-03 US disclosed
US-4029687-A HERBICIDES CIBA-GEIGY AG (CH) 1977-06-14 US disclosed
US-4004914-A HERBICIDES CIBA-GEIGY AG (CH) 1977-01-25 US disclosed