Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | GLA | P06280 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.61 |
| ▸ | CASP7 | P55210 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718071 | 0.95 | KDM4E (0.78) | KDM4EHTTGLAALDH1A1HPGD | |
| SCHEMBL3722156 | 0.86 | KDM4E (0.67) | KDM4EHTTGLAALDH1A1HPGD | |
| SCHEMBL3719605 | 0.82 | KDM4E (0.58) | KDM4EHTTGLAALDH1A1HPGD | |
| SCHEMBL3720910 | 0.81 | LMNA (0.78) | KDM4EHTTGLAALDH1A1HPGD | |
| SCHEMBL3724662 | 0.81 | KDM4E (0.73) | KDM4EHTTGLAALDH1A1HPGD | |
| SCHEMBL3720247 | 0.80 | SCN9A (0.56) | KDM4EHTTGLAALDH1A1HPGD | |
| SCHEMBL3728038 | 0.80 | HRH4 (0.50) | KDM4EHTTGLAALDH1A1HPGD | |
| SCHEMBL1733760 | 0.80 | KDM4E (0.92) | KDM4EHTTGLAALDH1A1HPGD | |
| SCHEMBL1734353 | 0.79 | KDM4E (0.77) | KDM4EHTTGLAALDH1A1HPGD | |
| SCHEMBL3717767 | 0.78 | KDM4E (0.59) | KDM4EHTTGLAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |