Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840921 | 0.99 | DRD2 (0.41) | DRD2DRD3UCHL1PLAUCHEK1 | |
| Ammonia Solution, Strong SCHEMBL3729931 | 0.79 | DRD2 (0.41) | DRD2DRD3UCHL1PLAUADRA1A | |
| SCHEMBL841719 | 0.77 | DRD2 (0.42) | DRD2DRD3UCHL1PLAUADRA1A | |
| SCHEMBL3729955 | 0.76 | AKT2 (0.38) | DRD2UCHL1CHEK1AKT2HTR1A | |
| SCHEMBL839992 | 0.75 | HTR1D (0.44) | DRD2DRD3UCHL1HTR1DHTR1B | |
| SCHEMBL3320785 | 0.74 | HTR1A (0.63) | DRD2HTR1ACHRM5ADRA2AADRA2B | |
| SCHEMBL3315799 | 0.74 | HTR1A (0.63) | DRD2HTR1ACHRM5ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL3317883 | 0.73 | HTR1A (0.61) | DRD2HTR1ACHRM5ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL4651195 | 0.73 | HTR1A (0.61) | DRD2HTR1ACHRM5ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL4651200 | 0.73 | HTR1A (0.61) | DRD2HTR1ACHRM5ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |