SCHEMBL3730480

SCHEMBL3730480

OP(O)(=S)Oc1cc(Cl)c(Cl)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MPO P05164 1/20 0.38
TPO P07202 1/20 0.38
EPX P11678 1/20 0.38
LPO P22079 1/20 0.38
LMNA P02545 2/20 0.36
NR1I2 O75469 1/20 0.34
ADRA2A P08913 1/20 0.34
ADORA3 P0DMS8 1/20 0.34
ADRA2B P18089 1/20 0.34
ADRA2C P18825 1/20 0.34
TACR2 P21452 1/20 0.34
DRD1 P21728 1/20 0.34
SLC6A2 P23975 1/20 0.34
HTR2A P28223 1/20 0.34
HTR2C P28335 1/20 0.34
ADORA1 P30542 1/20 0.34
SLC6A4 P31645 1/20 0.34
OPRM1 P35372 1/20 0.34
DRD3 P35462 1/20 0.34
OPRK1 P41145 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4981635 0.84 AHR (0.33) TDP1AHR
SCHEMBL8754761 0.83 MPO (0.36) MPOTPOEPXLPOLMNA
SCHEMBL27411935 0.83 LMNA (0.34) MPOTPOEPXLPOLMNA
SCHEMBL11322565 0.79 NR1I2 (0.35) MPOTPOEPXLPOLMNA
SCHEMBL3728711 0.78 TDP1 (0.39) MPOTPOEPXLPOLMNA
SCHEMBL15315299 0.77 INPPL1 (0.58) LMNAALDH1A1MAPTNPSR1HPGD
SCHEMBL1641526 0.77 TDP1 (0.57) LMNANR1I2ADORA3SLC6A2SLC6A3
SCHEMBL11442874 0.76 TDP1 (0.36) MPOTPOEPXLPOLMNA
Ronnel SCHEMBL6736758 0.74 TDP1 (0.53) MPOTPOEPXLPOLMNA
SCHEMBL18406961 0.74 LMNA (0.42) LMNANR1I2ADRA2AADORA3ADRA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5762808-A Destruction of electron affinic contaminants during water treatment using free radical processes RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1998-06-09 US claimed
EP-0289909-A2 All aqueous formulations of organo-phosphorous pesticides BASF Corporation (US) 1988-11-09 EP claimed
US-20100168030-A1 Methods and compositions for treatment of organophosphate-caused pathology ARMY, UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE 2010-07-01 US disclosed
EP-1315421-B1 ORGANOPHOSPHOROUS COMPOSITIONS BASF CORP (US) 2004-06-02 EP disclosed
US-6566349-B1 Applying blend of the insecticide with fatty acid containing crop oil concentrate for controlling insect populations of the lepidopteran order in crops BASF CORPORATION 2003-05-20 US disclosed
US-4605431-A ANTIDOTES FOR THIOLCARBAMATE HERBICIDES; PLANT SAFENING AGENTS MONSANTO COMPANY (US) 1986-08-12 US disclosed