Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | PGD | P52209 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6671589 | 0.89 | TDP1 (0.52) | TDP1PGDMMP1MMP2MMP3 | |
| SCHEMBL3731295 | 0.88 | TDP1 (0.35) | TDP1PGD | |
| Ethylene Glycol SCHEMBL3746397 | 0.88 | TDP1 (0.46) | TDP1PGDMMP1MMP2MMP3 | |
| Propylene Glycol SCHEMBL3731200 | 0.87 | TDP1 (0.39) | TDP1PGDMMP1MMP2MMP3 | |
| 1,4-Butanediol SCHEMBL3733202 | 0.85 | TDP1 (0.43) | TDP1PGDMMP1MMP2MMP3 | |
| Propylene Glycol SCHEMBL3732522 | 0.84 | TDP1 (0.37) | TDP1MMP9MMP13 | |
| Propylene Glycol SCHEMBL3728467 | 0.83 | TDP1 (0.45) | TDP1MMEPGDMMP1MMP2 | |
| Di(Hydroxyethyl)Ether SCHEMBL3728903 | 0.82 | TDP1 (0.41) | TDP1 | |
| Propylene Glycol SCHEMBL3729380 | 0.79 | TDP1 (0.39) | TDP1PGDMMP1MMP2MMP3 | |
| Propylene Glycol SCHEMBL3729121 | 0.77 | TDP1 (0.37) | TDP1MMEPGDSMN1; SMN2SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825178-B2 | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20070289481-A1 | Leveling Agent for Floor Polish and Aqueous Floor Polish Composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |