Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 2/20 | 0.32 |
| ▸ | PGD | P52209 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16407998 | 0.88 | PPARA (0.42) | TDP1PPARASMN1; SMN2PPARGSLC22A6 | |
| SCHEMBL2185057 | 0.88 | PPARA (0.42) | TDP1PPARASMN1; SMN2PPARGSLC22A6 | |
| SCHEMBL3733573 | 0.87 | TDP1 (0.37) | TDP1PPARAPPARGPGD | |
| Ethylene Glycol SCHEMBL3729359 | 0.86 | PPARA (0.39) | TDP1PPARASMN1; SMN2PPARGSLC22A6 | |
| Propylene Glycol SCHEMBL3728907 | 0.86 | TDP1 (0.34) | TDP1SMN1; SMN2SLC22A6MMEOR51E2 | |
| 1,4-Butanediol SCHEMBL3738776 | 0.83 | PPARA (0.37) | TDP1PPARASMN1; SMN2PPARGPPARD | |
| Propylene Glycol SCHEMBL3732367 | 0.83 | GPR84 (0.39) | GPR84 | |
| Propylene Glycol SCHEMBL3741431 | 0.81 | TDP1 (0.40) | TDP1SMN1; SMN2SLC22A6MMEOR51E2 | |
| Di(Hydroxyethyl)Ether SCHEMBL3726945 | 0.80 | TSHR (0.41) | TDP1PPARAPPARGPPARD | |
| SCHEMBL726980 | 0.79 | SMN1; SMN2 (0.39) | TDP1SMN1; SMN2SLC22A6PGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825178-B2 | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20070289481-A1 | Leveling Agent for Floor Polish and Aqueous Floor Polish Composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |