Sugi Predict

Sugi Predict / Compounds / SCHEMBL3732364

SCHEMBL3732364

SCHEMBL3732364

C#Cc1cnc2ccc(OC(CC)C(=O)NC(C)(COC)COC)cc2c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.35
▸ POLB P06746 1/20 0.35
▸ ALDH1A1 P00352 4/20 0.35
▸ F2 P00734 1/20 0.35
▸ GLA P06280 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ LMNA P02545 3/20 0.34
▸ TP53 P04637 2/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ HSD17B10 Q99714 2/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ ADORA3 P0DMS8 1/20 0.33
▸ ADORA2A P29274 1/20 0.33
▸ ADORA1 P30542 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ TSHR P16473 2/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3738998 0.91 ALDH1A1 (0.35) MAPTPOLBALDH1A1F2GLA
SCHEMBL3740890 0.87 SCN9A (0.39) MAPTPOLBALDH1A1F2GLA
SCHEMBL3732164 0.86 ALDH1A1 (0.34) MAPTALDH1A1F2GLAHPGD
SCHEMBL3732370 0.85 MAPT (0.35) MAPTPOLBALDH1A1F2GLA
SCHEMBL535354 0.84 MAPT (0.34) MAPTPOLBALDH1A1F2GLA
SCHEMBL535353 0.84 MAPT (0.34) MAPTPOLBALDH1A1F2GLA
SCHEMBL535391 0.83 HSD17B10 (0.35) MAPTPOLBALDH1A1F2GLA
SCHEMBL535392 0.83 HSD17B10 (0.35) MAPTPOLBALDH1A1F2GLA
SCHEMBL535078 0.82 MAPT (0.34) MAPTPOLBALDH1A1F2GLA
SCHEMBL15469576 0.82 ALDH1A1 (0.42) MAPTPOLBALDH1A1LMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8415272-B2 Quinoline derivatives and their use as fungicides SYNGENTA CROP PROTECTION LLC (US) 2013-04-09 — — US disclosed
US-8415272-B2 Quinoline derivatives and their use as fungicides SYNGENTA CROP PROTECTION LLC (US) 2013-04-09 — — US disclosed
US-8415272-B2 Quinoline derivatives and their use as fungicides SYNGENTA CROP PROTECTION LLC (US) 2013-04-09 — — US disclosed
US-20100280068-A1 QUINOLINE DERIVATIVES AND THEIR USE AS FUNGICIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-11-04 — — US disclosed
US-20100280068-A1 QUINOLINE DERIVATIVES AND THEIR USE AS FUNGICIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-11-04 — — US disclosed
US-20100280068-A1 QUINOLINE DERIVATIVES AND THEIR USE AS FUNGICIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-11-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100280068-A1 QUINOLINE DERIVATIVES AND THEIR USE AS FUNGICIDES CYP1A1, CYP3A7, CYP1A2 MAPT 3438/4885POLB 4575/4885ALDH1A1 350/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.