Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PTPRF | P10586 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CPB1 | P15086 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL3728907 | 0.90 | TDP1 (0.34) | GPR84USP2PTPRFPTPN2PTPN1 | |
| SCHEMBL11764465 | 0.90 | GPR84 (0.41) | GPR84PTPRFPTPN2PTPN1MMP9 | |
| SCHEMBL3738483 | 0.89 | TDP1 (0.40) | GPR84USP2PTPRFPTPN2PTPN1 | |
| Ethylene Glycol SCHEMBL3732513 | 0.88 | TSHR (0.41) | GPR84PTPRFPTPN2PTPN1MMP9 | |
| 1,4-Butanediol SCHEMBL3731759 | 0.87 | TSHR (0.39) | GPR84PTPRFPTPN2PTPN1MMP9 | |
| SCHEMBL3733695 | 0.86 | TDP1 (0.41) | GPR84USP2PTPRFPTPN2PTPN1 | |
| SCHEMBL18141616 | 0.84 | GPR84 (0.44) | GPR84PTPN1MMP9MMP8MMP13 | |
| Di(Hydroxyethyl)Ether SCHEMBL3742578 | 0.84 | TSHR (0.55) | GPR84USP2PTPRFPTPN2PTPN1 | |
| SCHEMBL18139501 | 0.83 | GPR84 (0.47) | GPR84PTPN1MMP9MMP8MMP13 | |
| SCHEMBL4243745 | 0.83 | GPR84 (0.47) | GPR84PTPN1MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825178-B2 | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20070289481-A1 | Leveling Agent for Floor Polish and Aqueous Floor Polish Composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |