Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.31 |
| ▸ | PTPRF | P10586 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 2/20 | 0.31 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL3732367 | 0.90 | GPR84 (0.39) | GPR84USP2PTPRFPTPN2PTPN1 | |
| SCHEMBL8034253 | 0.89 | TDP1 (0.37) | TDP1GPR84SMN1; SMN2CYP2C19SLC22A6 | |
| SCHEMBL3731765 | 0.88 | TDP1 (0.45) | TDP1HSD17B10USP2 | |
| Ethylene Glycol SCHEMBL3731973 | 0.87 | CYP2C19 (0.34) | TDP1GPR84SMN1; SMN2CYP2C19SLC22A6 | |
| Propylene Glycol SCHEMBL3729121 | 0.86 | TDP1 (0.37) | TDP1GPR84SMN1; SMN2SLC22A6MME | |
| 1,4-Butanediol SCHEMBL3742477 | 0.84 | GPR84 (0.34) | TDP1HSD17B10GPR84SMN1; SMN2CYP2C19 | |
| Di(Hydroxyethyl)Ether SCHEMBL3730783 | 0.83 | TSHR (0.44) | TDP1GPR84CYP2C19PTPRFPTPN2 | |
| SCHEMBL3738483 | 0.79 | TDP1 (0.40) | TDP1HSD17B10GPR84USP2PTPRF | |
| SCHEMBL4968928 | 0.79 | TDP1 (0.39) | TDP1SMN1; SMN2SLC22A6 | |
| SCHEMBL5939357 | 0.79 | HDAC2 (0.36) | TDP1USP2OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825178-B2 | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20070289481-A1 | Leveling Agent for Floor Polish and Aqueous Floor Polish Composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |