Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.47 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1606591 | 0.92 | KMT2A (0.54) | APPCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3746118 | 0.85 | CYP11B2 (0.43) | APPCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1605878 | 0.80 | KMT2A (0.55) | APPCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1606261 | 0.77 | CHRNB1 (0.51) | APPCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1606382 | 0.76 | CYP11B2 (0.46) | APPCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3676197 | 0.75 | APP (0.56) | APPCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL14603921 | 0.74 | KMT2A (0.46) | APPCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1606086 | 0.74 | CYP11B2 (0.55) | APPCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1606762 | 0.74 | KMT2A (0.58) | APPCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL28259817 | 0.74 | KMT2A (0.63) | APPKMT2AKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791141-B2 | Organic compounds | NOVARTIS AG (CH) | 2014-07-29 | — | — | US | disclosed |
| US-20100261698-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261698-A1 | ORGANIC COMPOUNDS | SLCO2B1, SLCO1B1, SLCO1B3 | APP 1593/4885CHRNB1 2629/4885CHRNB2 3544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.