SCHEMBL373443

SCHEMBL373443

C=Cc1cccc(Nc2cc(S(=O)(=O)O)c(N)c3c2C(=O)c2ccccc2C3=O)c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GNG2 P59768 5/20 0.74
GNB1 P62873 5/20 0.74
P2RY4 P51582 10/20 0.71
PHLPP2 Q6ZVD8 2/20 0.70
CYP1A2 P05177 2/20 0.70
CYP2C9 P11712 2/20 0.70
ALOX15 P16050 2/20 0.70
HSD17B10 Q99714 2/20 0.70
ALDH1A1 P00352 1/20 0.70
CYP3A4 P08684 1/20 0.70
HPGD P15428 1/20 0.70
MAPK1 P28482 1/20 0.70
CYP2C19 P33261 1/20 0.70
HIF1A Q16665 1/20 0.70
P2RY2 P41231 7/20 0.58
P2RY12 Q9H244 7/20 0.58
P2RY6 Q15077 4/20 0.57
CDK2 P24941 2/20 0.57
P2RY1 P47900 2/20 0.57
ENPP3 O14638 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30382062 0.89 GNG2 (0.77) GNG2GNB1P2RY4PHLPP2CYP1A2
SCHEMBL373494 0.89 GNG2 (0.77) GNG2GNB1P2RY4PHLPP2CYP1A2
SCHEMBL625105 0.86 GNG2 (0.78) GNG2GNB1P2RY4PHLPP2CYP1A2
SCHEMBL2778373 0.85 GNG2 (1.00) GNG2GNB1P2RY4PHLPP2CYP1A2
SCHEMBL791019 0.85 GNG2 (0.85) GNG2GNB1P2RY4PHLPP2CYP1A2
SCHEMBL29357302 0.85 GNG2 (0.85) GNG2GNB1P2RY4PHLPP2CYP1A2
SCHEMBL11119697 0.84 GNG2 (0.70) GNG2GNB1P2RY4PHLPP2CYP1A2
SCHEMBL15339732 0.84 GNG2 (0.70) GNG2GNB1P2RY4PHLPP2CYP1A2
SCHEMBL21844895 0.84 GNG2 (0.70) GNG2GNB1P2RY4PHLPP2CYP1A2
SCHEMBL3020872 0.84 GNG2 (0.98) GNG2GNB1P2RY4PHLPP2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3822296-B1 POLYMER MATERIAL MENICON CO LTD (JP) 2025-09-10 EP disclosed
US-20250115701-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2025-04-10 US disclosed
US-12209154-B2 Polymer material MENICON CO., LTD. (JP) 2025-01-28 US disclosed
WO-2023068316-A1 MATERIAL FOR SOFT CONTACT LENS HAVING CONTRAST IMPROVEMENT FUNCTION 興和株式会社 2023-04-27 WO disclosed
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
CN-112703213-A Polymer material 株式会社目立康 2021-04-23 CN disclosed
WO-2021020512-A1 DRUG-CONTAINING OPHTHALMIC LENS 興和株式会社 2021-02-04 WO disclosed
EP-3086162-B1 OCULAR LENS MENICON CO LTD (JP) 2019-04-17 EP disclosed
US-20180356561-A1 GEL, GEL MANUFACTURING METHOD, LENS, CONTACT LENS SURFACE MODIFIER, POLYMERIZABLE COMPOSITION, AND POLYMER JSR CORPORATION (JP) 2018-12-13 US disclosed
US-5416132-A Acrylamide modified acrylate modified polysiloxanes MENICON CO., LTD. (JP) 1995-05-16 US disclosed
EP-0381005-B1 Ocular lens material MENICON CO LTD (JP) 1995-01-11 EP disclosed
US-5346946-A Polysiloxane macromonomer MENICON CO., LTD (JP) 1994-09-13 US disclosed
EP-0600269-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1994-06-08 EP disclosed
EP-0584826-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0584764-A1 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0578087-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-01-12 EP disclosed
US-5041511-A Vinyl benzene acrylate or methacrylate crosslinking agent MENICON CO., LTD. (JP) 1991-08-20 US disclosed
US-4954586-A COPOLYMER OF A FLUORINE CONTAINING (METH)ACRYLATE, AN ALKYL (METH)ACRYLATE, A POLYSILOXANE AND A URETHANE CONTAINING POLYSILOXANE MENICON CO., LTD (JP) 1990-09-04 US disclosed
EP-0379146-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1990-07-25 EP disclosed