Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.59 |
| ▸ | CTSS | P25774 | 4/20 | 0.59 |
| ▸ | CTSB | P07858 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CTSK | P43235 | 3/20 | 0.55 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3735332 | 1.00 | CTSL (0.59) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL3731879 | 0.90 | CTSL (0.53) | CTSLCTSSCTSBMEN1KMT2A | |
| SCHEMBL3732674 | 0.88 | CTSL (0.58) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL11771667 | 0.85 | CTSL (0.55) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL7278892 | 0.85 | CTSL (0.55) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL7278888 | 0.85 | CTSL (0.55) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL3732278 | 0.84 | CYP3A4 (0.59) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL8662503 | 0.83 | CTSB (0.70) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL7860526 | 0.83 | CYP3A4 (0.57) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL27310595 | 0.82 | CYP3A4 (0.69) | CTSLCTSSCTSBCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825238-B2 | Antiviral methods employing double esters of 2′, 3′-dideoxy-3′-fluoroguanosine | MEDIVIR AB (SE) | 2010-11-02 | — | — | US | disclosed |
| US-6458772-B1 | Prodrugs | MEDIVIR AB (SE) | 2002-10-01 | — | — | US | disclosed |