Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 4/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL978541 | 0.89 | PTGES (0.52) | PTGESALDH1A1MAPTBCL2L1MCL1 | |
| SCHEMBL2801513 | 0.85 | PTGES (0.46) | PTGES | |
| SCHEMBL979564 | 0.84 | ALDH1A1 (0.58) | PTGESLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL13066212 | 0.81 | PTGES (0.42) | PTGESHDAC2HDAC6HTT | |
| SCHEMBL2803061 | 0.80 | SMPD1 (0.47) | PTGESNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL978913 | 0.80 | PTGES (0.47) | PTGESSMPD1 | |
| SCHEMBL2802236 | 0.78 | PTGES (0.47) | PTGESSMPD1 | |
| SCHEMBL2802216 | 0.78 | PTGES (0.46) | PTGES | |
| SCHEMBL2803367 | 0.76 | PTGES (0.47) | PTGESLMNAALDH1A1BCL2L1MCL1 | |
| SCHEMBL977333 | 0.74 | FLT1 (0.58) | PTGESALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132016-A1 | BIS-(SULFONYLAMINO) DERIVATIVES FOR TREATMENT OF PAIN AND INFLAMMATION | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |