Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 8/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18296234 | 0.93 | KMT2A (0.60) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL22048083 | 0.83 | KMT2A (0.53) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL27995000 | 0.80 | MAPK1 (0.51) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL1585290 | 0.78 | KDM4E (0.83) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL24316507 | 0.76 | KDM4E (0.60) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL18036255 | 0.75 | KDM4E (0.50) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL13177598 | 0.73 | KDM4E (0.57) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL27174552 | 0.73 | KDM4E (0.57) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL20255477 | 0.73 | ESR2 (0.50) | KMT2AKDM4EGLAHTTSMN1; SMN2 | |
| SCHEMBL14152280 | 0.72 | MAPK1 (0.57) | KMT2AKDM4EGLAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |