Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 3/20 | 0.78 |
| ▸ | WNT3A | P56704 | 3/20 | 0.78 |
| ▸ | ACHE | P22303 | 3/20 | 0.71 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15969047 | 0.88 | CTNNB1 (1.00) | CTNNB1WNT3AACHEPAX8LMNA | |
| SCHEMBL3730274 | 0.87 | ACHE (0.70) | CTNNB1WNT3AACHELMNAMAPT | |
| SCHEMBL4601794 | 0.87 | ACHE (0.73) | CTNNB1WNT3AACHELMNAL3MBTL1 | |
| SCHEMBL3735519 | 0.83 | ACHE (0.65) | CTNNB1WNT3AACHELMNAMAPT | |
| SCHEMBL9827940 | 0.82 | ACHE (0.64) | CTNNB1WNT3AACHEMAPTALDH1A1 | |
| SCHEMBL10455919 | 0.82 | CTNNB1 (0.83) | CTNNB1WNT3AACHEPAX8MAPT | |
| SCHEMBL28650786 | 0.81 | LMNA (0.76) | CTNNB1WNT3ALMNAMAPTL3MBTL1 | |
| SCHEMBL8071141 | 0.81 | CTNNB1 (0.61) | CTNNB1WNT3AACHEPAX8LMNA | |
| SCHEMBL4940823 | 0.81 | KMT2A (0.62) | CTNNB1WNT3ALMNAMAPTL3MBTL1 | |
| SCHEMBL31556192 | 0.79 | CTNNB1 (0.73) | CTNNB1WNT3AACHEPAX8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-B1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-7829563-B2 | Aminoamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HCRTR1, HCRTR2, HRH3 | CTNNB1 2968/4885WNT3A 3424/4885ACHE 3848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.