SCHEMBL37384

SCHEMBL37384

Clc1nc(Cl)c2[nH]cnc2n1

nearest known ligand 0.66

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.66
XDH P47989 1/20 0.59
KDM4E B2RXH2 1/20 0.48
PDPK1 O15530 1/20 0.44
GDA Q9Y2T3 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
TMIGD3 P0DMS9 1/20 0.43
HTR2C P28335 1/20 0.43
HTR2B P41595 1/20 0.43
ADORA3 P0DMS8 1/20 0.42
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8719273 0.98 DPP4 (0.63) DPP4XDHKDM4EPDPK1GDA
Hydrochloric Acid SCHEMBL4763244 0.98 DPP4 (0.63) DPP4XDHKDM4EPDPK1GDA
SCHEMBL11456967 0.98 DPP4 (0.63) DPP4XDHKDM4EPDPK1GDA
Alcohol SCHEMBL27897029 0.89 DPP4 (0.54) DPP4XDHKDM4ESMN1; SMN2TMIGD3
Purine SCHEMBL10869621 0.82 KDM4E (0.50) DPP4XDHKDM4ESMN1; SMN2TMIGD3
Tetrabuthylammonium SCHEMBL3029323 0.81 POLA1 (0.48) DPP4XDHADORA3
SCHEMBL2997392 0.79 DPP4 (0.61) DPP4XDHKDM4EPDPK1GDA
6-Chloroguanine SCHEMBL64059 0.79 DPP4 (1.00) DPP4PDPK1GDA
SCHEMBL1551198 0.79 DPP4 (0.61) DPP4XDHKDM4EPDPK1GDA
SCHEMBL2352414 0.79 DPP4 (0.61) DPP4XDHKDM4EPDPK1GDA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2319 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122036730-A Gαq/11 protein inhibitor with purine skeleton, and preparation method and application thereof 中山大学 2026-05-15 CN claimed
US-20250195498-A1 INHIBITOR OF CELLULAR PURINE NUCLEOTIDE SALVAGE PATHWAY ENZYME FOR USE IN THE TREATMENT AND/OR PREVENTION OF HELICOBACTER PYLORI INFECTION AND/OR DISEASE ASSOCIATED WITH SUCH INFECTION AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME UNIWERSYTET WARSZAWSKI (PL) 2025-06-19 US claimed
WO-2025129105-A1 COMPOSITION AND METHOD FOR DETECTION OF BIOMOLECULES VIA AROMATIC LABELING USING HETEROCYCLIC COMPOUNDS Life Technologies Corporation (US) 2025-06-19 WO claimed
EP-4560315-A2 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2025-05-28 EP claimed
CN-120025362-A Responsive prodrug, preparation method and application thereof 上海大学 2025-05-23 CN claimed
EP-3980554-B1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES HOFFMANN LA ROCHE (CH) 2025-03-26 EP claimed
CN-118515713-A Iridium (III) complex photosensitizer based on purine ligand, preparation method and application 四川大学 2024-08-20 CN claimed
CN-117986256-A Aggregation-induced emission type photosensitizer based on purine skeleton and preparation method and application thereof 四川大学 2024-05-07 CN claimed
CN-117987495-A Synthesis method of 2, 6-dichloropurine nucleoside 上海瑞合达医药科技有限公司 2024-05-07 CN claimed
CN-117467726-B Preparation method of purine nucleoside 天津凯莱英生物科技有限公司 2024-04-16 CN claimed
US-5118800-A Oligonucleotides possessing a primary amino group in the terminal nucleotide CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1992-06-02 US claimed
EP-0152965-B1 PROCESS FOR PREPARING 2,6-SUBSTITUTED-9-(1,3-DIHYDROXY-2-PROPOXY-MENTHYL)-PURINES AND CERTAIN DERIVATIVES SYNTEX (U.S.A.) INC. (US) 1990-10-24 EP claimed
EP-0391411-A2 3'-Substituted methyl nucleosides as antiviral agents Bristol-Myers Squibb Company (US) 1990-10-10 EP claimed
EP-0173059-B1 METHOD FOR THE PRODUCTION OF 2'-DEOXYADENOSINE COMPOUNDS BRIGHAM YOUNG UNIVERSITY (US) 1989-11-29 EP claimed
US-4801710-A Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives MERCK & CO., INC. (US) 1989-01-31 US claimed
US-4760137-A Method for the production of 2'-deoxyadenosine compounds BRIGHAM YOUNG UNIVERSITY (US) 1988-07-26 US claimed
US-4621140-A Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives SYNTEX (U.S.A.) INC. (US) 1986-11-04 US claimed
EP-0184473-A1 Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives MERCK & CO. INC. (US) 1986-06-11 EP claimed
EP-0173059-A2 Method for the production of 2'-deoxyadenosine compounds BRIGHAM YOUNG UNIVERSITY (US) 1986-03-05 EP claimed
EP-0152965-A2 Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxy-menthyl)-purines and certain derivatives SYNTEX (U.S.A.) INC. (US) 1985-08-28 EP claimed