SCHEMBL356178

SCHEMBL356178

Fc1nc(Cl)c2[nH]cnc2n1

nearest known ligand 0.61

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.61
XDH P47989 1/20 0.43
PDPK1 O15530 1/20 0.41
GDA Q9Y2T3 1/20 0.41
ADORA3 P0DMS8 1/20 0.40
POLA1 P09884 1/20 0.40
CDK2 P24941 1/20 0.39
ALDH1A1 P00352 1/20 0.39
PNP P00491 1/20 0.38
BRAF P15056 1/20 0.38
TNNI3K Q59H18 1/20 0.37
KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2526552 0.79 PDPK1 (0.44) DPP4XDHPDPK1GDAADORA3
SCHEMBL37384 0.79 DPP4 (0.66) DPP4XDHPDPK1GDAADORA3
Hydrochloric Acid SCHEMBL4763244 0.78 DPP4 (0.63) DPP4XDHPDPK1GDAADORA3
SCHEMBL11456967 0.78 DPP4 (0.63) DPP4XDHPDPK1GDAADORA3
SCHEMBL8719273 0.78 DPP4 (0.63) DPP4XDHPDPK1GDAADORA3
SCHEMBL2997392 0.76 DPP4 (0.61) DPP4XDHPDPK1GDAADORA3
SCHEMBL3002433 0.76 DPP4 (0.61) DPP4XDHPDPK1GDAADORA3
SCHEMBL11212991 0.76 PDPK1 (0.41) DPP4XDHPDPK1GDAADORA3
SCHEMBL2352414 0.76 DPP4 (0.61) DPP4XDHPDPK1GDAADORA3
SCHEMBL1551198 0.76 DPP4 (0.61) DPP4XDHPDPK1GDAADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 384 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4560315-A2 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2025-05-28 EP claimed
EP-3980554-B1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES HOFFMANN LA ROCHE (CH) 2025-03-26 EP claimed
CN-118422225-A Preparation method of polysubstituted cyclic ether compound 哈尔滨工业大学(深圳)(哈尔滨工业大学深圳科技创新研究院) 2024-08-02 CN claimed
CN-117467726-A Preparation method of purine nucleoside 天津凯莱英生物科技有限公司 2024-01-30 CN claimed
US-20220195497-A1 HYBRIDIZING all-LNA OLIGONUCLEOTIDES ROCHE DIAGNOSTICS OPERATIONS, INC. 2022-06-23 US claimed
EP-3980554-A1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2022-04-13 EP claimed
CN-113939599-A Hybrid all-LNA oligonucleotides 豪夫迈·罗氏有限公司 2022-01-14 CN claimed
WO-2020245377-A1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. HOFFMANN-LA ROCHE AG (CH) 2020-12-10 WO claimed
CN-108358927-A 1,4- bis- replaces 1,2,3- ribavirin analogs and its preparation method and application 郑州大学 2018-08-03 CN claimed
CN-105130989-B A kind of 2 fluoroadenine synthetic methods 新乡学院 2017-10-03 CN claimed
CN-102391356-B Steroid n-glycoside analogue taking dihydro-pyranoid ring as D ring and preparation and application thereof UNIV ZHENGZHOU 2013-05-01 CN claimed
CN-102659785-A 2-amino-6-aminomethylpurine compound and preparation method and application thereof UNIV SHANDONG 2012-09-12 CN claimed
CN-102391356-A Steroid n-glycoside analogue taking dihydro-pyranoid ring as D ring and preparation and application thereof UNIV ZHENGZHOU 2012-03-28 CN claimed
US-20110269178-A1 FLUORESCENT CDK INHIBITORS FOR TREATMENT OF CANCER GEORGETOWN UNIVERSITY (US) 2011-11-03 US claimed
EP-2330908-A1 FLUORESCENT CDK INHIBITORS FOR TREATMENT OF CANCER Georgetown University (US) 2011-06-15 EP claimed
WO-2010019967-A1 FLUORESCENT CDK INHIBITORS FOR TREATMENT OF CANCER GEORGETOWN UNIVERSITY (US) 2010-02-18 WO claimed
US-6369237-B1 ENZYME INHIBITORS OF DNA GLYCOLASE PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2002-04-09 US claimed
WO-1998039334-A9 DNA GLYCOSYLASE INHIBITORS, AND USES RELATED THERETO 1999-02-18 WO claimed
WO-1998039334-A1 DNA GLYCOSYLASE INHIBITORS, AND USES RELATED THERETO PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1998-09-11 WO claimed
US-5118800-A Oligonucleotides possessing a primary amino group in the terminal nucleotide CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1992-06-02 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110269178-A1 FLUORESCENT CDK INHIBITORS FOR TREATMENT OF CANCER CDK3, CDK6, CDK8 DPP4 2868/4885XDH 4313/4885PDPK1 241/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.