Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1989836 | 0.83 | S100A4 (0.53) | S100A4MAPTTP53LMNACYP1A2 | |
| SCHEMBL14855914 | 0.83 | S100A4 (0.53) | S100A4MAPTTP53LMNACYP1A2 | |
| SCHEMBL15129175 | 0.83 | S100A4 (0.53) | S100A4MAPTTP53LMNACYP1A2 | |
| SCHEMBL24399522 | 0.81 | S100A4 (0.52) | S100A4MAPTTP53LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL1995427 | 0.81 | S100A4 (0.52) | S100A4MAPTTP53LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL1987878 | 0.81 | S100A4 (0.52) | S100A4MAPTTP53LMNACYP1A2 | |
| SCHEMBL3063845 | 0.78 | ACHE (0.59) | S100A4ACHECYP19A1ANPEP | |
| SCHEMBL30539131 | 0.78 | ACHE (0.59) | S100A4ACHECYP19A1ANPEP | |
| SCHEMBL2599235 | 0.78 | S100A4 (1.00) | S100A4MAPTTP53LMNACYP1A2 | |
| SCHEMBL30661167 | 0.78 | S100A4 (1.00) | S100A4MAPTTP53LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829555-B1 | Drug targeting | THE UNIVERSITY OF MANCHESTER (GB) | 2010-11-09 | — | — | US | disclosed |
| EP-0988057-B1 | BIOREDUCTIVE CONJUGATES FOR DRUG TARGETING | UNIV MANCHESTER (GB) | 2003-08-27 | — | — | EP | disclosed |
| EP-1068338-A2 | ENHANCED PRODRUG ACTIVATION | Oxford Biomedica (UK) Limited (GB) | 2001-01-17 | — | — | EP | disclosed |
| EP-0988057-A1 | DRUG TARGETING | Theramark Limited (GB) | 2000-03-29 | — | — | EP | disclosed |
| WO-1999045127-A2 | ENHANCED PRODRUG ACTIVATION | OXFORD BIOMEDICA (UK) LIMITED (GB) | 1999-09-10 | — | — | WO | disclosed |
| WO-1998035701-A1 | DRUG TARGETING | THERAMARK LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |