Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 18/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 17/20 | 0.46 |
| ▸ | PGR | P06401 | 16/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3644414 | 1.00 | NR3C1 (0.46) | NR3C1NR3C2PGRHDAC1HDAC8 | |
| SCHEMBL3680318 | 0.87 | HDAC1 (0.46) | NR3C1NR3C2PGRHDAC1HDAC8 | |
| SCHEMBL3638909 | 0.87 | HDAC1 (0.46) | NR3C1NR3C2PGRHDAC1HDAC8 | |
| SCHEMBL13593767 | 0.82 | NR3C1 (0.47) | NR3C1NR3C2PGRMAPT | |
| SCHEMBL4078502 | 0.79 | NR3C2 (0.48) | NR3C1NR3C2PGRMAPT | |
| SCHEMBL3645992 | 0.77 | CHRM2 (0.46) | NR3C1NR3C2PGRMAPT | |
| SCHEMBL4069425 | 0.76 | NR3C1 (0.49) | NR3C1NR3C2PGRMAPT | |
| SCHEMBL4075473 | 0.74 | NR3C1 (0.47) | NR3C1NR3C2PGRMAPT | |
| SCHEMBL4071357 | 0.73 | NR3C1 (0.48) | NR3C1NR3C2PGRHDAC1HDAC6 | |
| SCHEMBL3686531 | 0.73 | L3MBTL1 (0.53) | NR3C1HDAC1HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183217-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2010-05-12 | — | — | EP | claimed |
| WO-2009015067-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-29 | — | — | WO | claimed |
| EP-2183217-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009015067-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-29 | — | — | WO | disclosed |