Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.31 |
| ▸ | USP2 | O75604 | 4/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL386861 | 0.67 | CYP1A2 (0.60) | CYP1A2ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL3740623 | 0.62 | GPR84 (0.39) | CYP1A2MEN1KMT2AHRH3TAAR1 | |
| SCHEMBL388675 | 0.62 | CYP1A2 (0.41) | CYP1A2ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL13660763 | 0.59 | GPR84 (0.43) | CYP2C19GPR84 | |
| SCHEMBL28018144 | 0.59 | GPR84 (0.43) | TDP1HPGDSTP53GPR84 | |
| SCHEMBL2666289 | 0.58 | MEN1 (0.56) | CYP1A2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL21459319 | 0.58 | TTK (0.41) | ALDH1A1HRH3TAAR1LMNAGPR84 | |
| SCHEMBL389509 | 0.58 | CYP1A2 (0.54) | CYP1A2ALDH1A1PPARDPPARAKMT2A | |
| SCHEMBL16210072 | 0.58 | MEN1 (0.59) | CYP1A2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL6362896 | 0.58 | MEN1 (0.82) | ALDH1A1MEN1KMT2APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803754-B2 | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level | ARENA PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-20070072804-A1 | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level | ARENA PHARMACEUTICALS (US) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072804-A1 | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level | GLP1R, GPR119, GIPR | CYP1A2 4033/4885CYP2C19 2935/4885ALDH1A1 2154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.