⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3431407 | 0.70 | — | — | |
| SCHEMBL2981077 | 0.70 | — | — | |
| SCHEMBL5929425 | 0.70 | — | — | |
| SCHEMBL722863 | 0.70 | — | — | |
| SCHEMBL724052 | 0.70 | — | — | |
| SCHEMBL608831 | 0.67 | — | — | |
| Guanidine SCHEMBL687217 | 0.67 | — | — | |
| SCHEMBL10597703 | 0.67 | — | — | |
| Hydroxyguanidine SCHEMBL8216664 | 0.67 | — | — | |
| SCHEMBL307358 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 283 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110092798-A | It is a kind of as the heterocyclic compound and its synthetic method of FGFR inhibitor and application | 上海新契博生物科技有限公司 | 2019-08-06 | — | — | CN | claimed |
| EP-2418205-B1 | Pyrimidine urea derivatives as kinase inhibitors | NOVARTIS AG (CH) | 2014-01-22 | — | — | EP | claimed |
| US-8552002-B2 | 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-[6-(2,6-dimethyl-pyridin-3-ylamino)-pyrimidin-4-yl]-1-methyl-urea; 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-methyl-1-{6-[4-(4-methyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-urea | NOVARTIS AG (CH) | 2013-10-08 | — | — | US | claimed |
| EP-2409969-B1 | Pyrimidine urea derivatives as kinase inhibitors | NOVARTIS AG (CH) | 2013-07-24 | — | — | EP | claimed |
| US-20130012704-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | DING QIANG (CN) | 2013-01-10 | — | — | US | claimed |
| US-20130012476-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2013-01-10 | — | — | US | claimed |
| EP-2418205-A1 | Pyrimidine urea derivatives as kinase inhibitors | Novartis AG (CH) | 2012-02-15 | — | — | EP | claimed |
| EP-2409969-A1 | Pyrimidine urea derivatives as kinase inhibitors | Novartis AG (CH) | 2012-01-25 | — | — | EP | claimed |
| EP-1761505-B1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-1799265-B1 | STABLE DOSING FORM OF PHENYLALANINE DERIVATIVES | WILEX AG (DE) | 2010-09-08 | — | — | EP | claimed |
| US-6689763-B2 | STREPTOMYCIN BACTERICIDES FOR TREATING INFECTIONS; CULTURES | WYETH HOLDINGS CORPORATION | 2004-02-10 | — | — | US | claimed |
| EP-0811002-B1 | BENZYLPIPERIDINES AND PIPERAZINES AS MUSCARINIC ANTAGONISTS | SCHERING CORP (US) | 2004-01-21 | — | — | EP | claimed |
| US-20030220468-A1 | Modified forms of pharmacologically active agents and uses therefor | MEDINOX, INC. | 2003-11-27 | — | — | US | claimed |
| US-20030186942-A1 | Compounds of use in the treatment of epilepsy, seizure, and electroconvulsive disorders | UNIVERSITY OF KENTUCKY | 2003-10-02 | — | — | US | claimed |
| US-20030104986-A1 | Streptomycin bactericides for treating infections; cultures | AMERICAN CYANAMID COMPANY (US) | 2003-06-05 | — | — | US | claimed |
| WO-2002085310-A2 | ANTIBIOTICS AA-896 | WYETH HOLDINGS CORPORATION (US) | 2002-10-31 | — | — | WO | claimed |
| US-20020103205-A1 | Muscarinic antagonists | LOWE DEREK (US) | 2002-08-01 | — | — | US | claimed |
| US-5883096-A | DI-N-SUBSTITUTED PIPERAZINE DERIVATIVES; ALZHEIMER*S DISEASE, COGNITION ACTIVATORS; SYNERGISTIC MIXTURES WITH ACETYLCHOLINESTERASE INHIBITORS | SCHERING CORPORATION (US) | 1999-03-16 | — | — | US | claimed |
| EP-0811002-A2 | BENZYLPIPERIDINES AND PIPERAZINES AS MUSCARINIC ANTAGONISTS | SCHERING CORPORATION (US) | 1997-12-10 | — | — | EP | claimed |
| WO-1996026196-A2 | BENZYLPIPERIDINES AND PIPERAZINES AS MUSCARINIC ANTAGONISTS | SCHERING CORPORATION (US) | 1996-08-29 | — | — | WO | claimed |