Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.30 |
| ▸ | CYP21A2 | P08686 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13100462 | 0.87 | — | — | |
| SCHEMBL12251504 | 0.78 | POLB (0.41) | EPHX2NAMPTALDH1A1POLBNPSR1 | |
| SCHEMBL5405216 | 0.77 | EPHX2 (0.44) | EPHX2ALDH1A1POLBCYP3A4KMT2A | |
| SCHEMBL16022965 | 0.77 | EPHX2 (0.44) | EPHX2NAMPTALDH1A1POLBL3MBTL1 | |
| SCHEMBL26203636 | 0.76 | LMNA (0.47) | EPHX2NAMPTALDH1A1CYP3A4CYP3A5 | |
| SCHEMBL19369112 | 0.76 | EPHX2 (0.38) | EPHX2NAMPTALDH1A1CYP3A4CYP3A5 | |
| SCHEMBL18896297 | 0.76 | EPHX2 (0.38) | EPHX2NAMPTALDH1A1POLBCYP3A4 | |
| SCHEMBL18711923 | 0.76 | PIK3CD (0.47) | EPHX2NAMPTALDH1A1POLBNPSR1 | |
| SCHEMBL24735804 | 0.75 | CA1 (0.48) | EPHX2ALDH1A1POLBCYP3A4KMT2A | |
| SCHEMBL15893903 | 0.75 | CA1 (0.48) | EPHX2ALDH1A1POLBCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825120-B2 | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas | CYTOKINETICS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-20070197504-A1 | Certain chemical entities, compositions and methods | CYTOKINETICS, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197504-A1 | Certain chemical entities, compositions and methods | TNNI3, TNNT2, MYLK2 | EPHX2 3695/4885NAMPT 3645/4885ALDH1A1 3619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.