SCHEMBL3741645

SCHEMBL3741645

C[C@@H](Oc1ccc(O/C(F)=C/c2ccc(F)cc2)cc1)C(=O)Nc1ccccc1F

nearest known ligand 0.63

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.63
POLB P06746 3/20 0.52
SMN1; SMN2 Q16637 4/20 0.49
MAPT P10636 2/20 0.49
LMNA P02545 2/20 0.49
HPGD P15428 1/20 0.46
ALDH1A1 P00352 2/20 0.46
TSHR P16473 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
HTT P42858 2/20 0.43
KMT2A Q03164 2/20 0.43
KDM4E B2RXH2 1/20 0.43
MEN1 O00255 1/20 0.43
ATM Q13315 1/20 0.43
MITF O75030 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
TP53 P04637 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3137549 1.00 GAA (0.63) GAAPOLBSMN1; SMN2MAPTLMNA
SCHEMBL3132078 0.94 GAA (0.65) GAAPOLBSMN1; SMN2MAPTLMNA
SCHEMBL3132092 0.94 GAA (0.65) GAAPOLBSMN1; SMN2MAPTLMNA
SCHEMBL3131936 0.93 GAA (0.61) GAAPOLBSMN1; SMN2MAPTLMNA
SCHEMBL3131928 0.93 GAA (0.61) GAAPOLBSMN1; SMN2MAPTLMNA
SCHEMBL3734429 0.92 GAA (0.60) GAAPOLBSMN1; SMN2MAPTLMNA
SCHEMBL3734431 0.92 GAA (0.60) GAAPOLBSMN1; SMN2MAPTLMNA
SCHEMBL13467572 0.79 GAA (0.82) GAAPOLBSMN1; SMN2LMNAHPGD
SCHEMBL3736340 0.78 TDP1 (0.41) GAASMN1; SMN2MAPTLMNAHPGD
SCHEMBL3134087 0.78 GAA (0.80) GAAPOLBSMN1; SMN2MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100279871-A1 OPTICALLY ACTIVE (R)-ARYLOXYPROPIONIC ACID AMIDES AND HERBICIDAL COMPOSITION COMPRISING SAME KYUNG NONG CORPORATION (KR) 2010-11-04 US claimed
US-8293774-B2 Optically active (R)-aryloxypropionic acid amides and herbicidal composition comprising same KYUNG NONG CORPORATION (KR) 2012-10-23 US disclosed
US-20100279871-A1 OPTICALLY ACTIVE (R)-ARYLOXYPROPIONIC ACID AMIDES AND HERBICIDAL COMPOSITION COMPRISING SAME KYUNG NONG CORPORATION (KR) 2010-11-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100279871-A1 OPTICALLY ACTIVE (R)-ARYLOXYPROPIONIC ACID AMIDES AND HERBICIDAL COMPOSITION COMPRISING SAME AADAC, DDT, NOTUM GAA 68/4885POLB 3881/4885SMN1; SMN2 3345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.