Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADSS2 | P30520 | 2/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.47 |
| ▸ | IGF2R | P11717 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AMDHD2 | Q9Y303 | 1/20 | 0.38 |
| ▸ | PGD | P52209 | 1/20 | 0.38 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.36 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.36 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.35 |
| ▸ | UMPS | P11172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16550 | 0.98 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RMEN1 | |
| SCHEMBL1493046 | 0.98 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RMEN1 | |
| SCHEMBL2591882 | 0.98 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RMEN1 | |
| SCHEMBL8056 | 0.98 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RMEN1 | |
| SCHEMBL135311 | 0.98 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RMEN1 | |
| SCHEMBL9736981 | 0.98 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RMEN1 | |
| SCHEMBL31153353 | 0.98 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RMEN1 | |
| SCHEMBL1532483 | 0.98 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RMEN1 | |
| SCHEMBL850081 | 0.98 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RMEN1 | |
| Water SCHEMBL5614144 | 0.97 | ADSS2 (0.51) | ADSS2FBP1P2RY14IGF2RMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130309697-A1 | BIOMARKERS FOR PROSTATE CANCER AND METHODS USING THE SAME | MITCHELL MATTHEW W (US) | 2013-11-21 | — | — | US | disclosed |
| US-8518650-B2 | Biomarkers for prostate cancer and methods using the same | METABOLON, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20100292331-A1 | Biomarkers for Prostate Cancer and Methods Using the Same | METABALON, INC. (US) | 2010-11-18 | — | — | US | disclosed |