ADSS2

Adenylosuccinate synthetase isozyme 2 · P30520 · ADSS2 on Sugi Atlas →

126 patent compounds predicted against ADSS2, 79 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Phosphohydantocidin Phosphohydantocidin (SCHEMBL2525635) 1.00 2/20
SCHEMBL29941388 SCHEMBL29941388 0.80 2/20
SCHEMBL29941488 SCHEMBL29941488 0.80 2/20
SCHEMBL20334729 SCHEMBL20334729 0.55 2/20
SCHEMBL8056 SCHEMBL8056 0.52 2/20
SCHEMBL16550 SCHEMBL16550 0.52 2/20
SCHEMBL135311 SCHEMBL135311 0.52 2/20
Fructose 1,6-Diphosphate Fructose 1,6-Diphosphate (SCHEMBL166666) 0.52 2/20
Fructose 1,6-Diphosphate Fructose 1,6-Diphosphate (SCHEMBL168244) 0.52 2/20
Fructose 1,6-Diphosphate Fructose 1,6-Diphosphate (SCHEMBL168245) 0.52 2/20
SCHEMBL850081 SCHEMBL850081 0.52 2/20
SCHEMBL1493046 SCHEMBL1493046 0.52 2/20
SCHEMBL1532483 SCHEMBL1532483 0.52 2/20
SCHEMBL2591882 SCHEMBL2591882 0.52 2/20
SCHEMBL9736981 SCHEMBL9736981 0.52 2/20
Fructose 1,6-Diphosphate Fructose 1,6-Diphosphate (SCHEMBL14905889) 0.52 2/20
Fructose 1,6-Diphosphate Fructose 1,6-Diphosphate (SCHEMBL19133126) 0.52 2/20
Fosfructose Fosfructose (SCHEMBL20731194) 0.52 2/20
Fructose 1,6-Diphosphate Fructose 1,6-Diphosphate (SCHEMBL28251436) 0.52 2/20
SCHEMBL31153353 SCHEMBL31153353 0.52 2/20

Clinical trials — most relevant to ADSS2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Metformin Use to Reduce Disparities in Newly Diagnosed Breast Cancer PHASE4WITHDRAWN
Bezafibrate Trial in CPT2 Deficiency PHASE3UNKNOWN
Safety and Efficacy of Hunterase PHASE3COMPLETED
Acelarin First Line Randomised Pancreatic Study PHASE2/PHASE3SUSPENDED
Folate Rechallenge PHASE2COMPLETED
Doxecitin and Doxribthymine in Adult Subjects With Thymidine Kinase 2 (TK2) Deficiency PHASE2RECRUITING
A Phase I/II Open-label Safety and Efficacy Study of LNP.UCD.ABE in Patients With Urea Cycle Disorders. PHASE1/PHASE2NOT_YET_RECRUITING
Circadian Rhythms and Sleep in Familial DSPS and ASPS nanCOMPLETED
Nitric Oxide Flux and Ureagenesis in Argininosuccinate Synthetase Deficiency (ASSD)(Citrullinemia I) nanCOMPLETED
Role of ADA SNPs in Subjects With Relapsing Multiple Sclerosis (RMS) nanUNKNOWN
TS Overexpression in SCLC: Mechanism and Therapeutic Targeting nanCOMPLETED
Characterization of Arrhythmia-induced Cardiomyopathy nanRECRUITING
Proof of Concept Creatine Supplementation for Homocystinuria Study nanACTIVE_NOT_RECRUITING
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart nanUNKNOWN
Investigation of ADA Enzyme Deficiency nanUNKNOWN
Age, Lifestyle, Muscle Mechanisms in Insulin Resistance nanCOMPLETED
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure nanUNKNOWN
Genetic and Metabolic Disease in Children nanRECRUITING
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte nanCOMPLETED
China Cognition and Aging Study nanRECRUITING
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD nanCOMPLETED
Study of Selected X-Linked Disorders: Aicardi Syndrome nanRECRUITING
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes nanRECRUITING
Identification and Characterization of Monogenic Diabetes nanCOMPLETED
Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome nanRECRUITING
Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder nanUNKNOWN
Gene Expression Profiling in Normal Tissue and Tumor Tissue From Patients With Colon Cancer That Has Spread to the Liver, Lungs, or Peritoneum nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ADSS2 binder may also engage these)

ProteinNameSimilarity
A7MBG0 1.000 A7MBG0 →
Q7ZY87 1.000 Q7ZY87 →
B5DGM3 1.000 B5DGM3 →
Q8N142 1.000 Q8N142 →
P46664 1.000 P46664 →
A4Z6H1 1.000 A4Z6H1 →
B6JUV1 1.000 B6JUV1 →
A4Z6H0 1.000 A4Z6H0 →
B8MZA3 1.000 B8MZA3 →
C4JYB4 1.000 C4JYB4 →
P28650 1.000 P28650 →
Q561L1 1.000 Q561L1 →
A1KT71 1.000 A1KT71 →
Q2UQQ2 1.000 Q2UQQ2 →
Q5ZJL5 1.000 Q5ZJL5 →
B3S0D3 1.000 B3S0D3 →
Q6P875 1.000 Q6P875 →
A5PJR4 1.000 A5PJR4 →
B5DGM4 1.000 B5DGM4 →
B2VXY5 1.000 B2VXY5 →
B1XU85 1.000 B1XU85 →
A6VYL0 1.000 A6VYL0 →
B2AWF0 1.000 B2AWF0 →
A6R8V2 1.000 A6R8V2 →
Q2KYA7 1.000 Q2KYA7 →
A2QB52 1.000 A2QB52 →
Q4URT6 1.000 Q4URT6 →
A8NDT2 1.000 A8NDT2 →
A7AU38 1.000 A7AU38 →
P0CQ35 1.000 P0CQ35 →