SCHEMBL374491

SCHEMBL374491

COc1cc(N=C=O)cc(OC)c1OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.47
ALDH1A1 P00352 3/20 0.47
HPGD P15428 3/20 0.47
TDP1 Q9NUW8 1/20 0.47
ACHE P22303 1/20 0.46
MAPT P10636 2/20 0.45
CA9 Q16790 1/20 0.45
PTGS2 P35354 1/20 0.42
CYP1A1 P04798 1/20 0.40
CYP1B1 Q16678 1/20 0.40
ERN1 O75460 1/20 0.40
KDM4E B2RXH2 2/20 0.39
HSD17B10 Q99714 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
G6PD P11413 1/20 0.39
CYP2C9 P11712 1/20 0.39
PKM P14618 1/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7530889 0.91 CYP1A2 (0.47) CYP3A4ALDH1A1HPGDTDP1ACHE
SCHEMBL21264352 0.90 CYP3A4 (0.43) CYP3A4ALDH1A1HPGDTDP1ACHE
SCHEMBL27189444 0.87 TDP1 (0.46) CYP3A4ALDH1A1HPGDTDP1ACHE
SCHEMBL30822599 0.87 TDP1 (0.46) CYP3A4ALDH1A1HPGDTDP1ACHE
SCHEMBL14014007 0.86 PTGS2 (0.43) CYP3A4ALDH1A1HPGDTDP1ACHE
SCHEMBL17874339 0.83 SMN1; SMN2 (0.47) CYP3A4ALDH1A1HPGDTDP1MAPT
SCHEMBL31711476 0.83 CYP3A4 (0.41) CYP3A4ALDH1A1HPGDTDP1ACHE
SCHEMBL22824635 0.83 CYP3A4 (0.38) CYP3A4ALDH1A1HPGDTDP1ACHE
SCHEMBL9358807 0.82 TUBB4A (0.47) CYP3A4ALDH1A1HPGDTDP1MAPT
SCHEMBL22824637 0.82 TPMT (0.41) CYP3A4ALDH1A1HPGDTDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 280 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 EP claimed
EP-0123146-A2 Compound with antiinflammatory activity, process for preparation thereof and pharmaceutical compositions therefrom CHIESI FARMACEUTICI S.p.A. (IT) 1984-10-31 EP claimed
EP-3774961-B1 ADDUCTS OF AMINE CATALYSTS FOR PRODUCING ISOCYANURATE POLYMERS COVESTRO DEUTSCHLAND AG (DE) 2025-01-15 EP disclosed
EP-4464727-A1 ESTERIFIED ETHANOLAMINES FOR THE PREPARATION OF ISOCYANURATE POLYMERS Covestro Deutschland AG (DE) 2024-11-20 EP disclosed
US-20240150515-A1 Low Viscosity Catalyst Compositions for Producing Isocyanurate Polymers COVESTRO DEUTSCHLAND AG (DE) 2024-05-09 US disclosed
EP-4298140-A1 LOW VISCOSITY CATALYST COMPOSITIONS FOR PRODUCING ISOCYANURATE POLYMERS Covestro Deutschland AG (DE) 2024-01-03 EP disclosed
CN-116917364-A Low viscosity catalyst composition for producing isocyanurate polymers 科思创德国股份有限公司 2023-10-20 CN disclosed
CN-112020525-B Adducts of amine catalysts for preparing isocyanurate polymers 科思创知识产权两合公司 2023-05-16 CN disclosed
US-20220363809-A1 POLYMERIZABLE COMPOSITIONS FOR PREPARING POLYISOCYANURATE-BASED PLASTICS HAVING EXTENDED WORKLIFE COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) 2022-11-17 US disclosed
WO-2022179939-A1 LOW VISCOSITY CATALYST COMPOSITIONS FOR PRODUCING ISOCYANURATE POLYMERS COVESTRO DEUTSCHLAND AG (DE) 2022-09-01 WO disclosed
CN-114040934-A Polymerizable composition for producing polyisocyanurate-based plastics having extended pot life 科思创知识产权两合公司 2022-02-11 CN disclosed
EP-0138491-A2 Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters ORTHO PHARMACEUTICAL CORPORATION (US) 1985-04-24 EP disclosed
US-4497815-A 1-(N-Substituted carbamoyl)-5-fluorouracil derivatives and the carcinostatic agents containing same as active ingredients Ozaki, Shoichiro (JP) 1985-02-05 US disclosed
EP-0127182-A1 1-Phenylalkyl-4-(mercapto and carbamylthio)alkyl-piperazines and -homopiperazines and their use in the treatment of allergic diseases Boehringer Ingelheim Pharmaceuticals Inc. (US) 1984-12-05 EP disclosed
EP-0123146-A2 Compound with antiinflammatory activity, process for preparation thereof and pharmaceutical compositions therefrom CHIESI FARMACEUTICI S.p.A. (IT) 1984-10-31 EP disclosed
US-4252804-A TRANQUILIZERS, ANTICONVULSANTS, MUSCLE RELAXANTS METABIO-JOULLIE (FR) 1981-02-24 US disclosed
US-4046909-A Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants MCNEIL LABORATORIES, INCORPORATED (US) 1977-09-06 US disclosed
US-4024258-A Composition of and method for reducing hypertension with a 1-[1-(indol-3-ylethyl)-piperazin-4-yl]-3-substituted urea AMERICAN HOECHST CORPORATION (US) 1977-05-17 US disclosed
US-3998958-A Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants MCNEIL LABORATORIES, INCORPORATED (US) 1976-12-21 US disclosed
US-3948918-A HYPOTENSIVE AMERICAN HOECHST CORPORATION (US) 1976-04-06 US disclosed