Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 6/20 | 0.68 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3745289 | 1.00 | CYP2C9 (0.68) | CYP2C9TRPM8CYP3A4TRPA1NPY5R | |
| SCHEMBL2773588 | 0.90 | CYP3A4 (0.55) | CYP2C9TRPM8CYP3A4TRPA1NPY5R | |
| SCHEMBL2773591 | 0.90 | CYP3A4 (0.55) | CYP2C9TRPM8CYP3A4TRPA1NPY5R | |
| SCHEMBL2771431 | 0.90 | CYP2C9 (0.55) | CYP2C9TRPM8CYP3A4TRPA1NPY5R | |
| Hydrochloric Acid SCHEMBL3744936 | 0.90 | CYP3A4 (0.55) | CYP2C9TRPM8CYP3A4TRPA1NPY5R | |
| SCHEMBL2771428 | 0.90 | CYP2C9 (0.55) | CYP2C9TRPM8CYP3A4TRPA1NPY5R | |
| Hydrochloric Acid SCHEMBL3744931 | 0.90 | CYP3A4 (0.55) | CYP2C9TRPM8CYP3A4TRPA1NPY5R | |
| Hydrochloric Acid SCHEMBL3753770 | 0.89 | CYP2C9 (0.54) | CYP2C9TRPM8CYP3A4TRPA1NPY5R | |
| Hydrochloric Acid SCHEMBL3753775 | 0.89 | CYP2C9 (0.54) | CYP2C9TRPM8CYP3A4TRPA1NPY5R | |
| SCHEMBL3743357 | 0.87 | CYP2C9 (0.51) | CYP2C9TRPM8CYP3A4TRPA1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217060-B2 | Benzimidazole derivatives useful as TRP M8 receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-07-10 | — | — | US | claimed |
| US-20100292276-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2010-11-18 | — | — | US | claimed |
| US-8217060-B2 | Benzimidazole derivatives useful as TRP M8 receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-07-10 | — | — | US | disclosed |
| US-20100292276-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292276-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS | TRPM8, TRPV1, TRPA1 | CYP2C9 2805/4885TRPM8 1/4885CYP3A4 2735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.