Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | TDO2 | P48775 | 2/20 | 0.37 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14321246 | 0.83 | CYP2D6 (0.47) | HIF1AADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL30606564 | 0.82 | CFD (0.41) | HIF1AADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL10416174 | 0.82 | HIF1A (0.41) | HIF1AADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL26599132 | 0.82 | CFD (0.41) | HIF1AADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL2058870 | 0.80 | TSHR (0.50) | HIF1AADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL14663977 | 0.78 | HIF1A (0.53) | HIF1AADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL14663994 | 0.78 | HIF1A (0.53) | HIF1AADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL16276059 | 0.78 | HIF1A (0.53) | HIF1AADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL17061810 | 0.78 | PDE2A (0.43) | — | |
| SCHEMBL14321599 | 0.77 | TSHR (0.41) | TSHRALDH1A1LMNAMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030144524-A1 | With an aromatic derivative carrying at least one hydroxyl functional group, wherein the electron-withdrawing group present on the carbonyl compound is selected from fluoroalkyl derivatives, esters, including orthoesters, and nitriles and | RHODIA CHIMIE, FRANCE | 2003-07-31 | — | — | US | claimed |
| US-20010004670-A1 | Process for the condensation of a carbonyl compound with an aromatic derivative in a basic medium | RHODIA CHIMIE (FR) | 2001-06-21 | — | — | US | claimed |
| EP-1082284-A1 | CONDENSATION METHOD FOR A CARBONYL COMPOUND ON AN AROMATIC DERIVATIVE IN A BASIC MEDIUM | RHODIA CHIMIE (FR) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062853-A1 | CONDENSATION METHOD FOR A CARBONYL COMPOUND ON AN AROMATIC DERIVATIVE IN A BASIC MEDIUM | RHODIA CHIMIE (FR) | 1999-12-09 | — | — | WO | claimed |
| US-8273890-B2 | Thiophene-imidazopyridines | 4SC AG (DE) | 2012-09-25 | — | — | US | disclosed |
| US-20100278833-A1 | THIOPHENE-IMIDAZOPYRIDINES | 4SC AG (DE) | 2010-11-04 | — | — | US | disclosed |
| WO-2009003911-A1 | THIOPHENE-IMIDAZOPYRIDINES | 4SC AG (DE) | 2009-01-08 | — | — | WO | disclosed |
| US-20030144524-A1 | With an aromatic derivative carrying at least one hydroxyl functional group, wherein the electron-withdrawing group present on the carbonyl compound is selected from fluoroalkyl derivatives, esters, including orthoesters, and nitriles and | RHODIA CHIMIE, FRANCE | 2003-07-31 | — | — | US | disclosed |
| US-6541674-B2 | Electron-withdrawing group present on carbonyl compound is selected from fluoroalkyl derivatives, esters, including orthoesters, and nitrites and condensation is carried out in basic medium | RHODIA CHIMIE (FR) | 2003-04-01 | — | — | US | disclosed |
| US-20010004670-A1 | Process for the condensation of a carbonyl compound with an aromatic derivative in a basic medium | RHODIA CHIMIE (FR) | 2001-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100278833-A1 | THIOPHENE-IMIDAZOPYRIDINES | PIKFYVE, PIP4K2B, PIP5K1B | HIF1A 3696/4885ADRB2 3949/4885ADRB1 2580/4885 |
| US-20010004670-A1 | Process for the condensation of a carbonyl compound with an aromatic derivative in a basic medium | NCAPH, ODC1, NCAPD2 | HIF1A 1122/4885ADRB2 2013/4885ADRB1 2320/4885 |
| US-20030144524-A1 | With an aromatic derivative carrying at least one hydroxyl functional group, wherein the electron-withdrawing group present on the carbonyl compound is selected from fluoroalkyl derivatives, esters, including orthoesters, and nitriles and | ECE2, HCN4, ETV6 | HIF1A 2158/4885ADRB2 1876/4885ADRB1 2750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.