Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 4/20 | 0.35 |
| ▸ | CHUK | O15111 | 4/20 | 0.35 |
| ▸ | AKT1 | P31749 | 4/20 | 0.35 |
| ▸ | AKT2 | P31751 | 4/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.35 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | PIM1 | P11309 | 3/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748382 | 1.00 | CYP3A4 (0.42) | CYP3A4CYP2C9TRPM8IKBKBCHUK | |
| SCHEMBL3750520 | 0.87 | CYP3A4 (0.54) | CYP3A4CYP2C9TRPM8IKBKBCHUK | |
| SCHEMBL2773346 | 0.87 | CYP3A4 (0.54) | CYP3A4CYP2C9TRPM8IKBKBCHUK | |
| SCHEMBL3750516 | 0.85 | CYP3A4 (0.43) | CYP3A4CYP2C9TRPM8IKBKBCHUK | |
| SCHEMBL3750518 | 0.85 | CYP3A4 (0.43) | CYP3A4CYP2C9TRPM8IKBKBCHUK | |
| SCHEMBL3748409 | 0.85 | MAP4K1 (0.37) | CYP3A4CYP2C9TRPM8IKBKBCHUK | |
| SCHEMBL3748411 | 0.85 | MAP4K1 (0.37) | CYP3A4CYP2C9TRPM8IKBKBCHUK | |
| SCHEMBL3738984 | 0.83 | CYP3A4 (0.50) | CYP3A4CYP2C9TRPM8IKBKBCHUK | |
| SCHEMBL3738975 | 0.83 | CYP3A4 (0.50) | CYP3A4CYP2C9TRPM8IKBKBCHUK | |
| Hydrochloric Acid SCHEMBL3745405 | 0.83 | CYP3A4 (0.49) | CYP3A4CYP2C9TRPM8ABL1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217060-B2 | Benzimidazole derivatives useful as TRP M8 receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-07-10 | — | — | US | claimed |
| US-20100292276-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2010-11-18 | — | — | US | claimed |
| US-8217060-B2 | Benzimidazole derivatives useful as TRP M8 receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-07-10 | — | — | US | disclosed |
| US-20100292276-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292276-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS | TRPM8, TRPV1, TRPA1 | CYP3A4 2735/4885CYP2C9 2805/4885TRPM8 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.