Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.50 |
| ▸ | WNT1 | P04628 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374881 | 1.00 | ABL1 (0.54) | ABL1RAB9ANPC1TSHRNPSR1 | |
| SCHEMBL29706156 | 0.90 | ABL1 (0.64) | ABL1RAB9ANPC1TSHRNPSR1 | |
| SCHEMBL27903680 | 0.90 | ABL1 (0.64) | ABL1RAB9ANPC1TSHRNPSR1 | |
| SCHEMBL374854 | 0.84 | ABL1 (0.58) | ABL1RAB9ANPC1TSHRNPSR1 | |
| SCHEMBL31241035 | 0.84 | NPC1 (0.62) | ABL1RAB9ANPC1TSHRNPSR1 | |
| SCHEMBL31241087 | 0.84 | RAB9A (0.58) | ABL1RAB9ANPC1TSHRNPSR1 | |
| SCHEMBL31241003 | 0.82 | RAB9A (0.60) | ABL1RAB9ANPC1TSHRNPSR1 | |
| SCHEMBL13189354 | 0.82 | RAB9A (0.60) | ABL1RAB9ANPC1TSHRNPSR1 | |
| SCHEMBL15991159 | 0.79 | ALDH1A1 (0.46) | ABL1RAB9ANPC1WNT1GSK3B | |
| SCHEMBL13826035 | 0.79 | ALDH1A1 (0.46) | ABL1RAB9ANPC1WNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637507-B2 | Bicyclic compounds as inhibitors of diacylglycerol acyltransferase | MERCK SHARP & DOHME CORP. (US) | 2014-01-28 | — | — | US | disclosed |
| EP-2408766-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Schering Corporation (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010107765-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |