Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 20/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.69 |
| ▸ | PGR | P06401 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 10/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5798007 | 0.91 | NR3C1 (0.61) | NR3C1CYP3A4PGRKCNH2NR3C2 | |
| SCHEMBL5799170 | 0.86 | NR3C1 (0.50) | NR3C1CYP3A4PGRNR3C2 | |
| SCHEMBL4555711 | 0.86 | NR3C1 (0.54) | NR3C1CYP3A4PGRKCNH2NR3C2 | |
| SCHEMBL3752990 | 0.85 | NR3C1 (0.49) | NR3C1CYP3A4PGRKCNH2NR3C2 | |
| SCHEMBL3685155 | 0.84 | NR3C1 (0.63) | NR3C1CYP3A4PGRKCNH2NR3C2 | |
| SCHEMBL3755290 | 0.83 | NR3C1 (0.54) | NR3C1CYP3A4PGRNR3C2 | |
| SCHEMBL6669693 | 0.83 | NR3C1 (0.64) | NR3C1CYP3A4PGRNR3C2 | |
| SCHEMBL4554361 | 0.82 | NR3C1 (0.58) | NR3C1CYP3A4PGRKCNH2NR3C2 | |
| SCHEMBL292321 | 0.81 | NR3C1 (1.00) | NR3C1CYP3A4PGRKCNH2NR3C2 | |
| SCHEMBL6669369 | 0.79 | NR3C1 (0.53) | NR3C1CYP3A4PGRKCNH2NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190431-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST FOR TREATING OR CONTROLLING ANTERIOR-SEGMENT INFLAMMATION | Bausch & Lomb Incorporated (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009023471-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST FOR TREATING OR CONTROLLING ANTERIOR-SEGMENT INFLAMMATION | BAUSCH & LOMB INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |