SCHEMBL374945

SCHEMBL374945

CC1(C)CCCC(C)(C)N1C(O)CO

nearest known ligand 0.39

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.39
NFKB1 P19838 1/20 0.39
CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11548298 0.82 TSHR (0.39) TSHRNFKB1CYP2C19
SCHEMBL9192258 0.80 TSHR (0.38) TSHRNFKB1CYP2C19
SCHEMBL10763467 0.73 TSHR (0.43) TSHRNFKB1CYP2C19
SCHEMBL9786341 0.73 TSHR (0.43) TSHRNFKB1CYP2C19
SCHEMBL10970265 0.70 LMNA (0.43) TSHRNFKB1CYP2C19
SCHEMBL28325735 0.70 TSHR (0.33) TSHRNFKB1CYP2C19
SCHEMBL8090265 0.67 TSHR (0.37) TSHRNFKB1CYP2C19
SCHEMBL28326856 0.67 TSHR (0.32) TSHRNFKB1CYP2C19
SCHEMBL27961792 0.67 TSHR (0.57) TSHRNFKB1CYP2C19
SCHEMBL11775876 0.67 TSHR (0.38) TSHRNFKB1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2311049-B1 IMPROVED HARD GRADE EPR INSULATION COMPOSITIONS GEN CABLE TECHNOLOGIES CORP (US) 2014-08-27 EP disclosed
US-8729392-B2 Thermoplastic polyurethane material with enhanced fluid immersion and water absorption capabilities GENERAL CABLE TECHNOLOGIES CORPORATION (US) 2014-05-20 US disclosed
US-8283391-B2 Tree resistant insulation compositions GENERAL CABLE TECHNOLOGIES CORPORATION (US) 2012-10-09 US disclosed
EP-2410010-A1 Improved lead-free insulation compositions containing metallocene polymers General Cable Technologies Corporation (US) 2012-01-25 EP disclosed
US-20110155416-A1 TREE RESISTANT INSULATION COMPOSITIONS GENERAL CABLE TECHNOLOGIES CORPORATION (US) 2011-06-30 US disclosed
US-7968623-B2 Tree resistant insulation compositions GENERAL CABLE TECHNOLOGIES CORP. (US) 2011-06-28 US disclosed
EP-2311049-A2 IMPROVED HARD GRADE EPR INSULATION COMPOSITIONS General Cable Technologies Corporation (US) 2011-04-20 EP disclosed
US-7915339-B2 Insulation compositions containing metallocene polymers GENERAL CABLE TECHNOLOGIES CORPORATION (US) 2011-03-29 US disclosed
US-20110011615-A1 THERMOPLASTIC POLYURETHANE MATERIAL WITH ENHANCED FLUID IMMERSION AND WATER ABSORPTION CAPABILITIES General Cable Technologies Corpoation (US) 2011-01-20 US disclosed
US-7858711-B2 Lead-free insulation compositions containing metallocene polymers General CableTechnologies Corporation (US) 2010-12-28 US disclosed
EP-1948728-A2 IMPROVED LEAD-FREE INSULATION COMPOSITIONS CONTAINING METALLOCENE POLYMERS General Cable Technologies Corporation (US) 2008-07-30 EP disclosed
WO-2008013661-A2 SILANE FUNCTIONAL ADHESIVE COMPOSITION AND METHOD OF BONDING A WINDOW TO A SUBSTRATE WITHOUT A PRIMER DOW GLOBAL TECHNOLOGIES INC. (US) 2008-01-31 WO disclosed
US-20070213433-A1 Polymer may be metallocene based, non metallocene based, hindered amine light stabilizers, mercapto compounds, and optionally, amine antioxidants, improved electrical and mechanical properties; without use of custom polymers such as elastomer terpolymer containing 5-vinyl-2-norbornene as base resin GENERAL CABLE TECHNOLOGIES CORPORATION 2007-09-13 US disclosed
US-20070100032-A1 Lead-free insulation compositions containing metallocene polymers GENERAL CABLE TECHNOLOGIES CORPORATION 2007-05-03 US disclosed
WO-2007050688-A2 IMPROVED LEAD-FREE INSULATION COMPOSITIONS CONTAINING METALLOCENE POLYMERS GENERAL CABLE TECHNOLOGIES CORPORATION (US) 2007-05-03 WO disclosed
WO-2007050696-A2 FLUORESCENT ARTICLE HAVING MULTIPLE LAYERS AVERY DENNISON CORPORATION (US) 2007-05-03 WO disclosed
US-20050252680-A1 Insulation compositions containing metallocene polymers GENERAL CABLE TECHNOLOGIES CORPORATION 2005-11-17 US disclosed
US-20050133248-A1 Insulation compositions containing metallocene polymers GENERAL CABLE TECHNOLOGIES CORPORATION 2005-06-23 US disclosed
US-6825253-B2 NOVEL ADDITIVE SYSTEMS FOR METALLOCENE BASED FILLED CABLE INSULATION ARE DISCLOSED. THESE SYSTEMS PROVIDE EXCELLENT PROTECTION AGAINST THERMAL DEGRADATION, BETTER CURE STATE AND REDUCED DISSIPATION FACTOR AFTER PROLONGED HEAT EXPOSURE WITH GENERAL CABLE TECHNOLOGIES CORPORATION 2004-11-30 US disclosed
US-20040014858-A1 Novel additive systems for metallocene based filled cable insulation are disclosed. These systems provide excellent protection against thermal degradation, better cure state and reduced dissipation factor after prolonged heat exposure with GENERAL CABLE TECHNOLOGIES CORPORATION 2004-01-22 US disclosed