Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.61 |
| ▸ | RXRB | P28702 | 1/20 | 0.61 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.60 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.60 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.55 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.55 |
| ▸ | RARB | P10826 | 5/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | ADH5 | P11766 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12432162 | 0.91 | HCRTR1 (0.60) | RXRARXRBHCRTR1HCRTR2PTPN11 | |
| SCHEMBL7169585 | 0.85 | PTPN11 (0.77) | PTPN11PLA2G4BRARB | |
| SCHEMBL5599370 | 0.84 | NQO1 (0.54) | HCRTR1HCRTR2SMN1; SMN2MAPTFFAR1 | |
| SCHEMBL3750017 | 0.84 | SRD5A2 (0.60) | RXRARXRBHCRTR1HCRTR2PTPN11 | |
| SCHEMBL9394698 | 0.83 | NR4A2 (0.64) | RXRARXRBSRD5A2PLA2G4BSMN1; SMN2 | |
| SCHEMBL23602940 | 0.82 | HSD17B1 (0.55) | HCRTR1HCRTR2PLA2G4BRARBSMN1; SMN2 | |
| SCHEMBL2228731 | 0.82 | HCRTR1 (0.56) | RXRARXRBHCRTR1HCRTR2PTPN11 | |
| SCHEMBL29997664 | 0.82 | HSD17B1 (0.55) | HCRTR1HCRTR2PLA2G4BRARBSMN1; SMN2 | |
| SCHEMBL202683 | 0.81 | PLA2G4B (0.74) | RXRARXRBHCRTR1HCRTR2SRD5A2 | |
| SCHEMBL28656189 | 0.81 | HSD17B10 (0.66) | HCRTR1HCRTR2SRD5A2RARBADH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838543-B2 | Melanin Concentrating Hormone Receptor 1; Obesity; 4'-Fluoro-biphenyl-4-carboxylic acid {2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}amide; 4-Cyclohexyl-N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-benzooxazol-5-yl}-benzamide; 2-aminobenzoxazoles or 2-aminobenzothiazoles | ELI LILLY AND COMPANY (US) | 2010-11-23 | — | — | US | disclosed |
| US-20090170913-A1 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2009-07-02 | — | — | US | disclosed |
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170913-A1 | NOVEL MCH RECEPTOR ANTAGONISTS | MCHR1, MCHR2, MC1R | RXRA 510/4885RXRB 496/4885HCRTR1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.