SCHEMBL3750843

SCHEMBL3750843

CN1CCN(CCOc2nccc(C(C#N)c3nc4ccccc4s3)n2)CC1

nearest known ligand 0.66

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPK10 P53779 11/20 0.66
MAPK9 P45984 10/20 0.66
MAPK8 P45983 2/20 0.61
SRC P12931 2/20 0.43
LTA4H P09960 5/20 0.40
MEN1 O00255 2/20 0.38
MAPT P10636 2/20 0.38
KMT2A Q03164 2/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
THRB P10828 1/20 0.38
HTT P42858 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3742425 0.90 MAPK10 (0.75) MAPK10MAPK9MAPK8SRCLTA4H
SCHEMBL3748955 0.87 MAPK10 (0.81) MAPK10MAPK9MAPK8LTA4HMEN1
SCHEMBL3753376 0.85 MAPK10 (0.70) MAPK10MAPK9MAPK8SRCMEN1
SCHEMBL4020776 0.83 MAPK10 (0.68) MAPK10MAPK9MAPK8SRC
SCHEMBL3751308 0.82 MAPK10 (0.72) MAPK10MAPK9MAPK8MEN1MAPT
SCHEMBL3746644 0.82 MAPK10 (0.72) MAPK10MAPK9MAPK8MEN1MAPT
SCHEMBL3752602 0.81 MAPK10 (0.70) MAPK10MAPK9MAPK8MEN1MAPT
SCHEMBL2886155 0.81 MAPK10 (0.61) MAPK10MAPK9MAPK8
SCHEMBL3740598 0.80 MAPK10 (0.85) MAPK10MAPK9MAPK8LTA4HMEN1
SCHEMBL1518836 0.80 MAPK10 (1.00) MAPK10MAPK9MAPK8MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7838522-B2 Benzothiazole formulations and use thereof ARES TRADING S.A. (CH) 2010-11-23 US disclosed
US-7838522-B2 Benzothiazole formulations and use thereof ARES TRADING S.A. (CH) 2010-11-23 US disclosed
US-7838522-B2 Benzothiazole formulations and use thereof ARES TRADING S.A. (CH) 2010-11-23 US disclosed
EP-1812072-B1 BENZOTHIAZOLE FORMULATIONS AND USE THEREOF ARES TRADING SA (CH) 2008-10-22 EP disclosed
US-20080051397-A1 Benzothiazole Formulations and Use Thereof ARES TRADING S.A. (CH) 2008-02-28 US disclosed
US-20080051397-A1 Benzothiazole Formulations and Use Thereof ARES TRADING S.A. (CH) 2008-02-28 US disclosed
US-20080051397-A1 Benzothiazole Formulations and Use Thereof ARES TRADING S.A. (CH) 2008-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080051397-A1 Benzothiazole Formulations and Use Thereof MGLL, MBOAT4, MBOAT1 MAPK10 3176/4885MAPK9 3960/4885MAPK8 4361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.