Sugi Predict

Sugi Predict / Compounds / SCHEMBL3751343

SCHEMBL3751343

SCHEMBL3751343

Nc1ccc(-c2nnc[nH]2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ASIC3 Q9UHC3 1/20 0.44
▸ ALDH1A1 P00352 7/20 0.42
▸ TP53 P04637 4/20 0.42
▸ CYP3A4 P08684 4/20 0.42
▸ TDP1 Q9NUW8 3/20 0.42
▸ NPC1 O15118 7/20 0.40
▸ RAB9A P51151 7/20 0.40
▸ MEN1 O00255 8/20 0.39
▸ KMT2A Q03164 8/20 0.39
▸ MAPT P10636 7/20 0.39
▸ KDM4E B2RXH2 6/20 0.39
▸ HSD17B10 Q99714 6/20 0.39
▸ SMN1; SMN2 Q16637 5/20 0.39
▸ HPGD P15428 5/20 0.39
▸ GFER P55789 3/20 0.39
▸ GLA P06280 3/20 0.39
▸ GAA P10253 3/20 0.39
▸ POLB P06746 2/20 0.39
▸ RECQL P46063 2/20 0.39
▸ RXFP1 Q9HBX9 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL158909 0.78 ATM (0.39) ALDH1A1TP53NPC1RAB9AMEN1
SCHEMBL969435 0.78 SMN1; SMN2 (0.44) ALDH1A1TP53NPC1RAB9AKDM4E
SCHEMBL13881958 0.78 NOTUM (0.44) ALDH1A1TP53NPC1RAB9AMAPT
SCHEMBL30312153 0.77 KDM4E (0.41) ALDH1A1TP53NPC1RAB9AMEN1
SCHEMBL3754960 0.76 ENPP2 (0.50) ALDH1A1TP53NPC1RAB9AMEN1
SCHEMBL4331812 0.76 LMNA (0.43) ALDH1A1TP53CYP3A4MAPTKDM4E
SCHEMBL23912330 0.74 CYP2A6 (0.35) ALDH1A1KDM4EHSD17B10SMN1; SMN2
SCHEMBL22080186 0.74 TP53 (0.44) ALDH1A1TP53KMT2ASMN1; SMN2TAAR1
SCHEMBL10866586 0.74 MAPT (0.44) ALDH1A1TP53NPC1RAB9AMAPT
SCHEMBL28863789 0.74 NISCH (0.40) ALDH1A1NPC1RAB9ALMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240368505-A1 FLUORINE-FREE CLEANING AGENT, PREPARATION METHOD THEREFOR AND USE THEREOF Tan Kah Kee Innovation Laboratory (CN) 2024-11-07 — — US claimed
CN-116731798-A Fluorine-free cleaning agent, and preparation method and application thereof 嘉庚创新实验室 2023-09-12 — — CN claimed
WO-2023133876-A1 FLUORINE-FREE CLEANING AGENT, PREPARATION METHOD THEREFOR AND USE THEREOF 嘉庚创新实验室 2023-07-20 — — WO claimed
CN-114317127-B Fluorine-free cleaning agent, and preparation method and application thereof 嘉庚创新实验室 2023-07-04 — — CN claimed
CN-114317127-A Fluoride-free cleaning agent, and preparation method and application thereof 嘉庚创新实验室 2022-04-12 — — CN claimed
US-20240368505-A1 FLUORINE-FREE CLEANING AGENT, PREPARATION METHOD THEREFOR AND USE THEREOF Tan Kah Kee Innovation Laboratory (CN) 2024-11-07 — — US disclosed
CN-116731798-B Fluorine-free cleaning agent, and preparation method and application thereof 嘉庚创新实验室 2024-07-23 — — CN disclosed
CN-116731798-A Fluorine-free cleaning agent, and preparation method and application thereof 嘉庚创新实验室 2023-09-12 — — CN disclosed
WO-2023133876-A1 FLUORINE-FREE CLEANING AGENT, PREPARATION METHOD THEREFOR AND USE THEREOF 嘉庚创新实验室 2023-07-20 — — WO disclosed
CN-114317127-B Fluorine-free cleaning agent, and preparation method and application thereof 嘉庚创新实验室 2023-07-04 — — CN disclosed
US-20230039917-A1 EXO-AZA SPIRO INHIBITORS OF MENIN-MLL INTERACTION JANSSEN PHARMACEUTICA NV (BE) 2023-02-09 — — US disclosed
EP-3481819-B1 COMPOUNDS AND THEIR USE FOR REDUCING URIC ACID LEVELS ACQUIST LLC (US) 2022-06-01 — — EP disclosed
US-20150232429-A1 SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS THE SCRIPPS RESEARCH INSTITUTE 2015-08-20 — — US disclosed
US-9018205-B2 Substituted pyrimidinyl-amines as protein kinase inhibitors THE SCRIPPS RESEARCH INSTITUTE (US) 2015-04-28 — — US disclosed
EP-2200436-B1 SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS SCRIPPS RESEARCH INST (US) 2015-01-21 — — EP disclosed
US-8530480-B2 Substituted pyrimidinyl-amines as protein kinase inhibitors THE SCRIPPS RESEARCH INSTITUTE (US) 2013-09-10 — — US disclosed
US-20130231336-A1 SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS THE SCRIPPS RESEARCH INSTITUTE (US) 2013-09-05 — — US disclosed
US-20100298312-A1 SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS THE SCRIPPS RESEARCH INSTITUTE (US) 2010-11-25 — — US disclosed
EP-2200436-A1 SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS The Scripps Research Institute (US) 2010-06-30 — — EP disclosed
WO-2009032861-A1 SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS THE SCRIPPS RESEARCH INSTITUTE (US) 2009-03-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130231336-A1 SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS MAP3K20, MAP3K5, MAP3K7 ASIC3 4503/4885ALDH1A1 4097/4885TP53 796/4885
US-20100298312-A1 SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS MAP3K20, MAP3K5, MAP3K7 ASIC3 4503/4885ALDH1A1 4097/4885TP53 796/4885
US-20230039917-A1 EXO-AZA SPIRO INHIBITORS OF MENIN-MLL INTERACTION BMI1, MLLT1, SUZ12 ASIC3 4617/4885ALDH1A1 2840/4885TP53 435/4885
US-20150232429-A1 SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS MAP3K20, MAP3K5, MAP3K7 ASIC3 4503/4885ALDH1A1 4097/4885TP53 796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.